EPHX1
Summary: Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| epoxide hydrolase 1 | MIM:132810 | Ensembl:ENSG00000143819 | HGNC:HGNC:3401 | PA27829 | 1q42.12 |
Gene Categories:
DRUGGABLE GENOMEGO terms in EPHX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031090 | organelle membrane |
| BP | TAS | GO:0006805 | xenobiotic metabolic process |
| BP | IEA | GO:0009636 | response to toxic substance |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IEA | GO:0019439 | aromatic compound catabolic process |
| BP | IDA | GO:0097176 | epoxide metabolic process |
| MF | IDA | GO:0004301 | epoxide hydrolase activity |
| MF | TAS | GO:0033961 | cis-stilbene-oxide hydrolase activity |
Gene expression in normal tissue: EPHX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPHX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| biocarta | eicosanoidpathway | eicosanoid metabolism |
| pharmgkb | PA145011114 | Warfarin Pathway, Pharmacodynamics |
| pharmgkb | PA145011115 | Phenytoin Pathway, Pharmacokinetics |
| pharmgkb | PA165817070 | Carbamazepine Pathway, Pharmacokinetics |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00634 | Carbamazepine Metabolism Pathway |
| wikipathways | WP3612 | Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling |
| wikipathways | WP3891 | Benzene metabolism |
| wikipathways | WP696 | Benzo(a)pyrene metabolism |
| wikipathways | WP699 | Aflatoxin B1 metabolism |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPHX1
CLASSFICATION
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