EPHX1


Summary: Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
epoxide hydrolase 1MIM:132810Ensembl:ENSG00000143819HGNC:HGNC:3401PA278291q42.12

Gene Categories:

DRUGGABLE GENOME

GO terms in EPHX1


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0016021integral component of membrane
CCIEAGO:0031090organelle membrane
BPTASGO:0006805xenobiotic metabolic process
BPIEAGO:0009636response to toxic substance
BPIEAGO:0014070response to organic cyclic compound
BPIEAGO:0019439aromatic compound catabolic process
BPIDAGO:0097176epoxide metabolic process
MFIDAGO:0004301epoxide hydrolase activity
MFTASGO:0033961cis-stilbene-oxide hydrolase activity

Gene expression in normal tissue: EPHX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHX1


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211945Phase I - Functionalization of compounds
biocartaeicosanoidpathwayeicosanoid metabolism
pharmgkbPA145011114Warfarin Pathway, Pharmacodynamics
pharmgkbPA145011115Phenytoin Pathway, Pharmacokinetics
pharmgkbPA165817070Carbamazepine Pathway, Pharmacokinetics
kegghsa00980Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)
kegghsa04976Bile secretion - Homo sapiens (human)
kegghsa05204Chemical carcinogenesis - Homo sapiens (human)
smpdbSMP00327Phenytoin (Antiarrhythmic) Action Pathway
smpdbSMP00634Carbamazepine Metabolism Pathway
wikipathwaysWP3612Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
wikipathwaysWP3891Benzene metabolism
wikipathwaysWP696Benzo(a)pyrene metabolism
wikipathwaysWP699Aflatoxin B1 metabolism
wikipathwaysWP702Metapathway biotransformation Phase I and II

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHX1

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