EPRS


Summary: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glutamyl-prolyl-tRNA synthetaseMIM:138295Ensembl:ENSG00000136628HGNC:HGNC:3418PA278371q41

Gene Categories:

DRUGGABLE GENOME

GO terms in EPRS


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004818glutamate-tRNA ligase activity
MFIBAGO:0004827proline-tRNA ligase activity
MFIDAGO:0004827proline-tRNA ligase activity
MFTASGO:0004827proline-tRNA ligase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0008270zinc ion binding
MFIDAGO:0035613RNA stem-loop binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0042803protein homodimerization activity
MFIPIGO:0051020GTPase binding
BPTASGO:0006418tRNA aminoacylation for protein translation
BPIBAGO:0006433prolyl-tRNA aminoacylation
BPIDAGO:0006433prolyl-tRNA aminoacylation
BPIDAGO:0017148negative regulation of translation
BPIMPGO:0017148negative regulation of translation
BPISSGO:0032869cellular response to insulin stimulus
BPIMPGO:0044539long-chain fatty acid import
BPTASGO:0065003protein-containing complex assembly
BPIDAGO:0071346cellular response to interferon-gamma
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCISSGO:0005886plasma membrane
CCHDAGO:0016020membrane
CCIBAGO:0017101aminoacyl-tRNA synthetase multienzyme complex
CCIDAGO:0017101aminoacyl-tRNA synthetase multienzyme complex
CCIDAGO:0097452GAIT complex
CCIDAGO:1990904ribonucleoprotein complex

Gene expression in normal tissue: EPRS

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPRS


DatabasePathway IDPathway Des.
kegghsa00860Porphyrin and chlorophyll metabolism - Homo sapiens (human)
kegghsa00970Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
netpathPathway_TCRTCR
humancycTRNA-CHARGING-PWYtRNA charging
wikipathwaysWP2371Parkinsons Disease Pathway
wikipathwaysWP3925Amino Acid metabolism
smpdbSMP00020Arginine and Proline Metabolism
smpdbSMP00188Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
smpdbSMP00207Prolidase Deficiency (PD)
smpdbSMP00208Prolinemia Type II
smpdbSMP00360Hyperprolinemia Type II
smpdbSMP00361Hyperprolinemia Type I
smpdbSMP00362Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
smpdbSMP00363Ornithine Aminotransferase Deficiency (OAT Deficiency)
smpdbSMP00504Creatine deficiency, guanidinoacetate methyltransferase deficiency
smpdbSMP00505Hyperornithinemia with gyrate atrophy (HOGA)
smpdbSMP00506Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]
smpdbSMP00507L-arginine:glycine amidinotransferase deficiency
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-2408517SeMet incorporation into proteins
reactomeR-HSA-2408522Selenoamino acid metabolism
reactomeR-HSA-379716Cytosolic tRNA aminoacylation
reactomeR-HSA-379724tRNA Aminoacylation
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-6782315tRNA modification in the nucleus and cytosol
reactomeR-HSA-71291Metabolism of amino acids and derivatives
reactomeR-HSA-72306tRNA processing
reactomeR-HSA-72766Translation
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPRS

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