EPRS
Summary: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species. Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
glutamyl-prolyl-tRNA synthetase | MIM:138295 | Ensembl:ENSG00000136628 | HGNC:HGNC:3418 | PA27837 | 1q41 |
Gene Categories:
DRUGGABLE GENOMEGO terms in EPRS
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0004818 | glutamate-tRNA ligase activity |
MF | IBA | GO:0004827 | proline-tRNA ligase activity |
MF | IDA | GO:0004827 | proline-tRNA ligase activity |
MF | TAS | GO:0004827 | proline-tRNA ligase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0005524 | ATP binding |
MF | IDA | GO:0008270 | zinc ion binding |
MF | IDA | GO:0035613 | RNA stem-loop binding |
MF | IPI | GO:0042802 | identical protein binding |
MF | IPI | GO:0042803 | protein homodimerization activity |
MF | IPI | GO:0051020 | GTPase binding |
BP | TAS | GO:0006418 | tRNA aminoacylation for protein translation |
BP | IBA | GO:0006433 | prolyl-tRNA aminoacylation |
BP | IDA | GO:0006433 | prolyl-tRNA aminoacylation |
BP | IDA | GO:0017148 | negative regulation of translation |
BP | IMP | GO:0017148 | negative regulation of translation |
BP | ISS | GO:0032869 | cellular response to insulin stimulus |
BP | IMP | GO:0044539 | long-chain fatty acid import |
BP | TAS | GO:0065003 | protein-containing complex assembly |
BP | IDA | GO:0071346 | cellular response to interferon-gamma |
CC | IBA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | ISS | GO:0005886 | plasma membrane |
CC | HDA | GO:0016020 | membrane |
CC | IBA | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
CC | IDA | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
CC | IDA | GO:0097452 | GAIT complex |
CC | IDA | GO:1990904 | ribonucleoprotein complex |
Gene expression in normal tissue: EPRS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPRS
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa00860 | Porphyrin and chlorophyll metabolism - Homo sapiens (human) |
kegg | hsa00970 | Aminoacyl-tRNA biosynthesis - Homo sapiens (human) |
netpath | Pathway_TCR | TCR |
humancyc | TRNA-CHARGING-PWY | tRNA charging |
wikipathways | WP2371 | Parkinsons Disease Pathway |
wikipathways | WP3925 | Amino Acid metabolism |
smpdb | SMP00020 | Arginine and Proline Metabolism |
smpdb | SMP00188 | Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) |
smpdb | SMP00207 | Prolidase Deficiency (PD) |
smpdb | SMP00208 | Prolinemia Type II |
smpdb | SMP00360 | Hyperprolinemia Type II |
smpdb | SMP00361 | Hyperprolinemia Type I |
smpdb | SMP00362 | Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) |
smpdb | SMP00363 | Ornithine Aminotransferase Deficiency (OAT Deficiency) |
smpdb | SMP00504 | Creatine deficiency, guanidinoacetate methyltransferase deficiency |
smpdb | SMP00505 | Hyperornithinemia with gyrate atrophy (HOGA) |
smpdb | SMP00506 | Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome] |
smpdb | SMP00507 | L-arginine:glycine amidinotransferase deficiency |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-2408517 | SeMet incorporation into proteins |
reactome | R-HSA-2408522 | Selenoamino acid metabolism |
reactome | R-HSA-379716 | Cytosolic tRNA aminoacylation |
reactome | R-HSA-379724 | tRNA Aminoacylation |
reactome | R-HSA-392499 | Metabolism of proteins |
reactome | R-HSA-6782315 | tRNA modification in the nucleus and cytosol |
reactome | R-HSA-71291 | Metabolism of amino acids and derivatives |
reactome | R-HSA-72306 | tRNA processing |
reactome | R-HSA-72766 | Translation |
reactome | R-HSA-8953854 | Metabolism of RNA |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPRS