Summary: This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Feb 2012].

coagulation factor II thrombin receptor like 2MIM:601919Ensembl:ENSG00000164220HGNC:HGNC:3539PA279485q13.3

GO terms in F2RL2

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0016324apical plasma membrane
CCIDAGO:0032991protein-containing complex
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007596blood coagulation
BPTASGO:0009611response to wounding
BPTASGO:0030168platelet activation
BPIBAGO:0035025positive regulation of Rho protein signal transduction
BPIBAGO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
BPIEAGO:0070493thrombin-activated receptor signaling pathway
MFTASGO:0004435phosphatidylinositol phospholipase C activity
MFIBAGO:0004930G-protein coupled receptor activity
MFTASGO:0004930G-protein coupled receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0015057thrombin-activated receptor activity

Gene expression in normal tissue: F2RL2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in F2RL2

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)
reactomeR-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76002Platelet activation, signaling and aggregation
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04610Complement and coagulation cascades - Homo sapiens (human)
pidcdc42_pathwayCDC42 signaling events
piderbb1_downstream_pathwayErbB1 downstream signaling
pidinsulin_pathwayInsulin Pathway
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidnephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
pidrhoa_pathwayRhoA signaling pathway
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
pidthrombin_par4_pathwayPAR4-mediated thrombin signaling events

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in F2RL2