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FBN3

Summary: This gene encodes a memebr of the fibrillin protein family. Fibrillins are extracellular matrix molecules that assemble into microfibrils in many connective tissues. This gene is most highly expressed in fetal tissues and its protein product is localized to extracellular microfibrils of developing skeletal elements, skin, lung, kidney, and skeletal muscle. This gene is potentially involved in Weill-Marchesani syndrome. [provided by RefSeq, Mar 2016].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
fibrillin 3	MIM:608529	Ensembl:ENSG00000142449	HGNC:HGNC:18794	PA38681	19p13.2

Gene Categories:

DRUGGABLE GENOME

GO terms in FBN3

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IBA	GO:0005201	extracellular matrix structural constituent
MF	IEA	GO:0005509	calcium ion binding
CC	IBA	GO:0031012	extracellular matrix
BP	IBA	GO:0009653	anatomical structure morphogenesis

Gene expression in normal tissue: FBN3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FBN3

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1474228	Degradation of the extracellular matrix
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1566948	Elastic fibre formation
reactome	R-HSA-1566948	Elastic fibre formation
reactome	R-HSA-2129379	Molecules associated with elastic fibres
reactome	R-HSA-2129379	Molecules associated with elastic fibres
wikipathways	WP3668	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD353	PD0325901	1
iGMDRD309	17AAG	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FBN3

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.