FBXO5


Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
F-box protein 5MIM:606013Ensembl:ENSG00000112029HGNC:HGNC:13584PA280456q25.2

Gene Categories:

TUMOR SUPPRESSOR

GO terms in FBXO5


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIPIGO:0019901protein kinase binding
MFIEAGO:0046872metal ion binding
MFIDAGO:1990948ubiquitin ligase inhibitor activity
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005819spindle
CCTASGO:0005829cytosol
BPTASGO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle
BPIEAGO:0001556oocyte maturation
BPIEAGO:0007057spindle assembly involved in female meiosis I
BPIBAGO:0007088regulation of mitotic nuclear division
BPISSGO:0007346regulation of mitotic cell cycle
BPIEAGO:0016050vesicle organization
BPIBAGO:0045835negative regulation of meiotic nuclear division
BPIEAGO:0046785microtubule polymerization
BPIEAGO:0051301cell division
BPIEAGO:1904667negative regulation of ubiquitin protein ligase activity

Gene expression in normal tissue: FBXO5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FBXO5


DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-174113SCF-beta-TrCP mediated degradation of Emi1
reactomeR-HSA-174143APC/C-mediated degradation of cell cycle proteins
reactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphase
reactomeR-HSA-176417Phosphorylation of Emi1
reactomeR-HSA-2555396Mitotic Metaphase and Anaphase
reactomeR-HSA-453276Regulation of mitotic cell cycle
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-539107Activation of E2F1 target genes at G1/S
reactomeR-HSA-68881Mitotic Metaphase/Anaphase Transition
reactomeR-HSA-68886M Phase
reactomeR-HSA-69205G1/S-Specific Transcription
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
kegghsa04114Oocyte meiosis - Homo sapiens (human)
pidplk1_pathwayPLK1 signaling events
wikipathwaysWP1858Mitotic G1-G1-S phases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FBXO5

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