Summary: The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008].

Fc fragment of IgE receptor IgMIM:147139Ensembl:ENSG00000158869HGNC:HGNC:3611PA280571q23.3

GO terms in FCER1G

Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001798positive regulation of type IIa hypersensitivity
BPIEAGO:0001805positive regulation of type III hypersensitivity
BPIEAGO:0001812positive regulation of type I hypersensitivity
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPIBAGO:0002283neutrophil activation involved in immune response
BPIBAGO:0002292T cell differentiation involved in immune response
BPIBAGO:0002431Fc receptor mediated stimulatory signaling pathway
BPIEAGO:0002554serotonin secretion by platelet
BPIEAGO:0006911phagocytosis, engulfment
BPIEAGO:0007229integrin-mediated signaling pathway
BPTASGO:0007596blood coagulation
BPIBAGO:0010543regulation of platelet activation
BPIBAGO:0016064immunoglobulin mediated immune response
BPIBAGO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
BPTASGO:0030168platelet activation
BPIEAGO:0030316osteoclast differentiation
BPIBAGO:0030593neutrophil chemotaxis
BPISSGO:0031623receptor internalization
BPIEAGO:0032623interleukin-2 production
BPIEAGO:0032733positive regulation of interleukin-10 production
BPISSGO:0032753positive regulation of interleukin-4 production
BPIEAGO:0032755positive regulation of interleukin-6 production
BPIEAGO:0032760positive regulation of tumor necrosis factor production
BPIEAGO:0032765positive regulation of mast cell cytokine production
BPIEAGO:0033026negative regulation of mast cell apoptotic process
BPIBAGO:0038094Fc-gamma receptor signaling pathway
BPIMPGO:0038095Fc-epsilon receptor signaling pathway
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPISSGO:0038156interleukin-3-mediated signaling pathway
BPIBAGO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I
BPIBAGO:0042742defense response to bacterium
BPIEAGO:0043306positive regulation of mast cell degranulation
BPTASGO:0043312neutrophil degranulation
BPIBAGO:0045087innate immune response
BPIEAGO:0045576mast cell activation
BPIBAGO:0050766positive regulation of phagocytosis
BPTASGO:0050900leukocyte migration
BPIMPGO:0051260protein homooligomerization
BPISSGO:0071404cellular response to low-density lipoprotein particle stimulus
BPIEAGO:0072659protein localization to plasma membrane
BPIEAGO:2000010positive regulation of protein localization to cell surface
CCTASGO:0005886plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIBAGO:0009897external side of plasma membrane
CCIDAGO:0009986cell surface
CCIBAGO:0032998Fc-epsilon receptor I complex
CCTASGO:0070821tertiary granule membrane
CCTASGO:0101003ficolin-1-rich granule membrane
MFIPIGO:0005515protein binding
MFIBAGO:0019767IgE receptor activity
MFIBAGO:0019863IgE binding
MFIBAGO:0019864IgG binding
MFIMPGO:0042803protein homodimerization activity

Gene expression in normal tissue: FCER1G

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FCER1G

DatabasePathway IDPathway Des.
reactomeR-HSA-114604GPVI-mediated activation cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilization
reactomeR-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilization
reactomeR-HSA-2871796FCERI mediated MAPK activation
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
reactomeR-HSA-2871809FCERI mediated Ca+2 mobilization
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-5621480Dectin-2 family
reactomeR-HSA-5621480Dectin-2 family
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-75892Platelet Adhesion to exposed collagen
reactomeR-HSA-76002Platelet activation, signaling and aggregation
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05310Asthma - Homo sapiens (human)
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
wikipathwaysWP3937Microglia Pathogen Phagocytosis Pathway
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FCER1G