Summary: The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012].

Fc fragment of IgG receptor IIIbMIM:610665Ensembl:ENSG00000162747HGNC:HGNC:3620PA280661q23.3

Gene Categories:


GO terms in FCGR3B

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006955immune response
BPTASGO:0043312neutrophil degranulation
CCTASGO:0005576extracellular region
CCTASGO:0005886plasma membrane
CCTASGO:0030667secretory granule membrane
CCIEAGO:0031225anchored component of membrane
CCHDAGO:0070062extracellular exosome
MFIEAGO:0019864IgG binding

Gene expression in normal tissue: FCGR3B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FCGR3B

DatabasePathway IDPathway Des.
kegghsa04145Phagosome - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05150Staphylococcus aureus infection - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
reactomeR-HSA-163125Post-translational modification: synthesis of GPI-anchored proteins
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6798695Neutrophil degranulation
biocartankcellspathwayras-independent pathway in nk cell-mediated cytotoxicity

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FCGR3B