FGF12


Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

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GO terms in FGF12


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0003254 regulation of membrane depolarization
BP TAS GO:0007165 signal transduction
BP TAS GO:0007267 cell-cell signaling
BP IEA GO:0007268 chemical synaptic transmission
BP TAS GO:0007399 nervous system development
BP TAS GO:0007507 heart development
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Gene expression in normal tissue: FGF12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FGF12


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Database
Pathway ID
Pathway Des.
reactome R-HSA-397014 Muscle contraction
reactome R-HSA-5576891 Cardiac conduction
reactome R-HSA-5576892 Phase 0 - rapid depolarisation
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP3931 ESC Pluripotency Pathways
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD309 17AAG 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGF12

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Cancer
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No matching records found

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