FGF12
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fibroblast growth factor 12 | MIM:601513 | Ensembl:ENSG00000114279 | HGNC:HGNC:3668 | PA28108 | 3q28-q29 |
GO terms in FGF12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0003254 | regulation of membrane depolarization |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IEA | GO:0007268 | chemical synaptic transmission |
| BP | TAS | GO:0007399 | nervous system development |
| BP | TAS | GO:0007507 | heart development |
| BP | IEA | GO:0008344 | adult locomotory behavior |
| BP | IEA | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0010765 | positive regulation of sodium ion transport |
| BP | IEA | GO:0050905 | neuromuscular process |
| BP | NAS | GO:0086002 | cardiac muscle cell action potential involved in contraction |
| BP | IMP | GO:0098908 | regulation of neuronal action potential |
| BP | ISS | GO:1902305 | regulation of sodium ion transmembrane transport |
| BP | IMP | GO:1905150 | regulation of voltage-gated sodium channel activity |
| BP | ISS | GO:2000649 | regulation of sodium ion transmembrane transporter activity |
| BP | IEA | GO:2001258 | negative regulation of cation channel activity |
| CC | TAS | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008083 | growth factor activity |
| MF | ISS | GO:0017080 | sodium channel regulator activity |
| MF | ISS | GO:0044325 | ion channel binding |
Gene expression in normal tissue: FGF12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGF12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576892 | Phase 0 - rapid depolarisation |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGF12
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