FGF13
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fibroblast growth factor 13 | MIM:300070 | Ensembl:ENSG00000129682 | HGNC:HGNC:3670 | PA28109 | Xq26.3-q27.1 |
GO terms in FGF13
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0001764 | neuron migration |
| BP | ISS | GO:0006814 | sodium ion transport |
| BP | ISS | GO:0007026 | negative regulation of microtubule depolymerization |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007399 | nervous system development |
| BP | ISS | GO:0007612 | learning |
| BP | ISS | GO:0007613 | memory |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | ISS | GO:0021766 | hippocampus development |
| BP | ISS | GO:0021795 | cerebral cortex cell migration |
| BP | IEA | GO:0032147 | activation of protein kinase activity |
| BP | ISS | GO:0045200 | establishment of neuroblast polarity |
| BP | ISS | GO:0046785 | microtubule polymerization |
| BP | ISS | GO:0048671 | negative regulation of collateral sprouting |
| BP | ISS | GO:0072659 | protein localization to plasma membrane |
| BP | ISS | GO:0098909 | regulation of cardiac muscle cell action potential involved in regulation of contraction |
| BP | IEA | GO:1990834 | response to odorant |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IPI | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | ISS | GO:0005874 | microtubule |
| CC | ISS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0014704 | intercalated disc |
| CC | ISS | GO:0016328 | lateral plasma membrane |
| CC | ISS | GO:0030175 | filopodium |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | ISS | GO:0030426 | growth cone |
| CC | ISS | GO:0043005 | neuron projection |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008017 | microtubule binding |
| MF | IEA | GO:0008083 | growth factor activity |
| MF | IDA | GO:0017080 | sodium channel regulator activity |
| MF | ISS | GO:0017080 | sodium channel regulator activity |
| MF | IGI | GO:0030295 | protein kinase activator activity |
| MF | ISS | GO:0044325 | ion channel binding |
| MF | ISS | GO:0048487 | beta-tubulin binding |
Gene expression in normal tissue: FGF13
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGF13
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-5576891 | Cardiac conduction |
| reactome | R-HSA-5576892 | Phase 0 - rapid depolarisation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD556 | Quizartinib | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD532 | Olaparib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGF13
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