FLT3LG
Summary: Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fms related tyrosine kinase 3 ligand | MIM:600007 | Ensembl:ENSG00000090554 | HGNC:HGNC:3766 | PA28182 | 19q13.33 |
GO terms in FLT3LG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005615 | extracellular space |
| CC | IBA | GO:0009986 | cell surface |
| CC | NAS | GO:0016020 | membrane |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0031233 | intrinsic component of external side of plasma membrane |
| BP | IEA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0030098 | lymphocyte differentiation |
| BP | IEA | GO:0030885 | regulation of myeloid dendritic cell activation |
| BP | IEA | GO:0032819 | positive regulation of natural killer cell proliferation |
| BP | IEA | GO:0032825 | positive regulation of natural killer cell differentiation |
| BP | IDA | GO:0035162 | embryonic hemopoiesis |
| BP | IEA | GO:0045663 | positive regulation of myoblast differentiation |
| BP | IEA | GO:0045787 | positive regulation of cell cycle |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048873 | homeostasis of number of cells within a tissue |
| BP | IEA | GO:0071864 | positive regulation of cell proliferation in bone marrow |
| BP | IEA | GO:0071866 | negative regulation of apoptotic process in bone marrow |
| BP | IEA | GO:0090290 | positive regulation of osteoclast proliferation |
| BP | IEA | GO:1901741 | positive regulation of myoblast fusion |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IEA | GO:0005125 | cytokine activity |
| MF | IBA | GO:0030971 | receptor tyrosine kinase binding |
| MF | IEA | GO:0030971 | receptor tyrosine kinase binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: FLT3LG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FLT3LG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449836 | Other interleukin signaling |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP3892 | Development of pulmonary dendritic cells and macrophage subsets |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FLT3LG
CLASSFICATION
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