FOSL2


Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
FOS like 2, AP-1 transcription factor subunitMIM:601575Ensembl:ENSG00000075426HGNC:HGNC:3798PA282152p23.2

GO terms in FOSL2


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIEAGO:0003682chromatin binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
CCIBAGO:0005634nucleus
CCTASGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
BPIEAGO:0003334keratinocyte development
BPIBAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0008219cell death
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048146positive regulation of fibroblast proliferation

Gene expression in normal tissue: FOSL2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOSL2


DatabasePathway IDPathway Des.
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
pidap1_pathwayAP-1 transcription factor network
piddeltanp63pathwayValidated transcriptional targets of deltaNp63 isoforms
pidfra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
biocartaranklpathwaybone remodeling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOSL2

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