FOSL2
Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
FOS like 2, AP-1 transcription factor subunit | MIM:601575 | Ensembl:ENSG00000075426 | HGNC:HGNC:3798 | PA28215 | 2p23.2 |
GO terms in FOSL2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IBA | GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
MF | IDA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
MF | IEA | GO:0003682 | chromatin binding |
MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
MF | IPI | GO:0005515 | protein binding |
CC | IBA | GO:0005634 | nucleus |
CC | TAS | GO:0005634 | nucleus |
CC | IDA | GO:0005654 | nucleoplasm |
BP | IEA | GO:0003334 | keratinocyte development |
BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
BP | IEA | GO:0006366 | transcription by RNA polymerase II |
BP | TAS | GO:0008219 | cell death |
BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
BP | IEA | GO:0048146 | positive regulation of fibroblast proliferation |
Gene expression in normal tissue: FOSL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOSL2
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
pid | ap1_pathway | AP-1 transcription factor network |
pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
pharmgkb | PA165985892 | Tacrolimus/Cyclosporine Pathway, Pharmacodynamics |
biocarta | ranklpathway | bone remodeling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOSL2