FOXE1
Summary: This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
forkhead box E1 | MIM:602617 | Ensembl:ENSG00000178919 | HGNC:HGNC:3806 | PA28223 | 9q22.33 |
GO terms in FOXE1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IDA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IMP | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
MF | IDA | GO:0043565 | sequence-specific DNA binding |
MF | IMP | GO:0043565 | sequence-specific DNA binding |
BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | NAS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
BP | IMP | GO:0006357 | regulation of transcription by RNA polymerase II |
BP | ISS | GO:0006590 | thyroid hormone generation |
BP | IBA | GO:0009653 | anatomical structure morphogenesis |
BP | NAS | GO:0009653 | anatomical structure morphogenesis |
BP | ISS | GO:0016477 | cell migration |
BP | IBA | GO:0030154 | cell differentiation |
BP | IEP | GO:0030878 | thyroid gland development |
BP | IMP | GO:0030878 | thyroid gland development |
BP | ISS | GO:0031069 | hair follicle morphogenesis |
BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
BP | IEP | GO:0048538 | thymus development |
BP | ISS | GO:0048562 | embryonic organ morphogenesis |
BP | IMP | GO:0060022 | hard palate development |
BP | IMP | GO:0060023 | soft palate development |
BP | IEP | GO:0060465 | pharynx development |
BP | IEA | GO:1904888 | cranial skeletal system development |
CC | IBA | GO:0005634 | nucleus |
CC | IDA | GO:0005634 | nucleus |
Gene expression in normal tissue: FOXE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOXE1
Database | Pathway ID | Pathway Des. |
---|
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
iGMDRD154 | NSC23766 | 3 |
iGMDRD446 | LY 2183240 | 4 |
iGMDRD341 | Triacsin c | 2 |
iGMDRD144 | NSC95397 | 5 |
iGMDRD494 | Neopeltolide | 3 |
iGMDRD330 | BRD4132 | 3 |
iGMDRD889 | Compound 7d-cis | 6 |
iGMDRD300 | Tozasertib | 2 |
iGMDRD886 | Compound 1541A | 3 |
iGMDRD60 | Quinoclamine | 3 |
iGMDRD268 | Cerulenin | 3 |
iGMDRD286 | Nsc 632839 | 3 |
iGMDRD188 | Piperlongumine | 8 |
iGMDRD872 | BRD7137 | 5 |
iGMDRD577 | BIX01294 | 3 |
iGMDRD77 | Itraconazole | 5 |
iGMDRD474 | Avrainvillamide | 2 |
iGMDRD137 | Indisulam | 2 |
iGMDRD255 | SB225002 | 3 |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in FOXE1