FOXP3


Summary: The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
forkhead box P3MIM:300292Ensembl:ENSG00000049768HGNC:HGNC:6106PA201094Xp11.23

GO terms in FOXP3


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIMPGO:0003677DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFNASGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MFIEAGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIPIGO:0035035histone acetyltransferase binding
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0042803protein homodimerization activity
MFIPIGO:0042826histone deacetylase binding
MFIDAGO:0043565sequence-specific DNA binding
MFIEAGO:0046872metal ion binding
MFNASGO:0051059NF-kappaB binding
MFIPIGO:0051525NFAT protein binding
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001782B cell homeostasis
BPIEAGO:0001816cytokine production
BPIEAGO:0002262myeloid cell homeostasis
BPTASGO:0002362CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
BPIEAGO:0002456T cell mediated immunity
BPIEAGO:0002513tolerance induction to self antigen
BPISSGO:0002667regulation of T cell anergy
BPIEAGO:0002669positive regulation of T cell anergy
BPIEAGO:0002677negative regulation of chronic inflammatory response
BPIDAGO:0002725negative regulation of T cell cytokine production
BPIMPGO:0002725negative regulation of T cell cytokine production
BPIEAGO:0002851positive regulation of peripheral T cell tolerance induction
BPNASGO:0006338chromatin remodeling
BPIEAGO:0006351transcription, DNA-templated
BPNASGO:0006355regulation of transcription, DNA-templated
BPIDAGO:0008285negative regulation of cell proliferation
BPIEPGO:0009615response to virus
BPTASGO:0030111regulation of Wnt signaling pathway
BPIGIGO:0031064negative regulation of histone deacetylation
BPIDAGO:0032088negative regulation of NF-kappaB transcription factor activity
BPIDAGO:0032689negative regulation of interferon-gamma production
BPIMPGO:0032689negative regulation of interferon-gamma production
BPIDAGO:0032693negative regulation of interleukin-10 production
BPIMPGO:0032700negative regulation of interleukin-17 production
BPIDAGO:0032703negative regulation of interleukin-2 production
BPIMPGO:0032703negative regulation of interleukin-2 production
BPIDAGO:0032713negative regulation of interleukin-4 production
BPIEAGO:0032714negative regulation of interleukin-5 production
BPIEAGO:0032715negative regulation of interleukin-6 production
BPIEAGO:0032720negative regulation of tumor necrosis factor production
BPIEAGO:0032753positive regulation of interleukin-4 production
BPIDAGO:0032792negative regulation of CREB transcription factor activity
BPTASGO:0032831positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
BPIEAGO:0032914positive regulation of transforming growth factor beta1 production
BPIEAGO:0033092positive regulation of immature T cell proliferation in thymus
BPIMPGO:0035066positive regulation of histone acetylation
BPIEAGO:0035067negative regulation of histone acetylation
BPIDAGO:0042036negative regulation of cytokine biosynthetic process
BPIDAGO:0042110T cell activation
BPIDAGO:0042130negative regulation of T cell proliferation
BPIMPGO:0042130negative regulation of T cell proliferation
BPNASGO:0043029T cell homeostasis
BPIDAGO:0043433negative regulation of DNA-binding transcription factor activity
BPIEAGO:0045077negative regulation of interferon-gamma biosynthetic process
BPIMPGO:0045085negative regulation of interleukin-2 biosynthetic process
BPTASGO:0045589regulation of regulatory T cell differentiation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPNASGO:0046007negative regulation of activated T cell proliferation
BPIEAGO:0048294negative regulation of isotype switching to IgE isotypes
BPIEAGO:0048302regulation of isotype switching to IgG isotypes
BPIDAGO:0050710negative regulation of cytokine secretion
BPIDAGO:0050777negative regulation of immune response
BPIEAGO:0050852T cell receptor signaling pathway
BPIMPGO:2000320negative regulation of T-helper 17 cell differentiation
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCNASGO:0032991protein-containing complex

Gene expression in normal tissue: FOXP3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOXP3


DatabasePathway IDPathway Des.
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP4079RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
wikipathwaysWP4105Transcriptional regulation by RUNX1
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8877330RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939256RUNX1 regulates transcription of genes involved in WNT signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD72Epirubicin1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXP3

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