FRMPD3
Summary: This gene encodes a protein that contains a PDZ (post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1) domain at the N-terminus followed by a FERM domain. The encoded protein is involved in signal transduction. The PDZ domain is thought to function in protein-protein interactions, mainly by binding to specific C-terminal peptides of other proteins. The FERM domain is found in proteins that are localized to the plasma membrane and are associated with the cytoskeleton. [provided by RefSeq, May 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FERM and PDZ domain containing 3 | MIM:301005 | Ensembl:ENSG00000147234 | HGNC:HGNC:29382 | PA143485474 | Xq22.3 |
GO terms in FRMPD3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | TAS | GO:0070821 | tertiary granule membrane |
| BP | TAS | GO:0043312 | neutrophil degranulation |
Gene expression in normal tissue: FRMPD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FRMPD3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FRMPD3
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