FTL
Summary: This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ferritin light chain | MIM:134790 | Ensembl:ENSG00000087086 | HGNC:HGNC:3999 | PA28412 | 19q13.33 |
GO terms in FTL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0008043 | intracellular ferritin complex |
| CC | IDA | GO:0008043 | intracellular ferritin complex |
| CC | HDA | GO:0016020 | membrane |
| CC | TAS | GO:0035578 | azurophil granule lumen |
| CC | IBA | GO:0044754 | autolysosome |
| CC | IDA | GO:0044754 | autolysosome |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0006826 | iron ion transport |
| BP | TAS | GO:0006879 | cellular iron ion homeostasis |
| BP | IBA | GO:0006880 | intracellular sequestering of iron ion |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | TAS | GO:0055072 | iron ion homeostasis |
| MF | IBA | GO:0004322 | ferroxidase activity |
| MF | IBA | GO:0004322 | ferroxidase activity |
| MF | IBA | GO:0005506 | iron ion binding |
| MF | IDA | GO:0005506 | iron ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008198 | ferrous iron binding |
| MF | IBA | GO:0008199 | ferric iron binding |
| MF | IEA | GO:0008199 | ferric iron binding |
| MF | IBA | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
Gene expression in normal tissue: FTL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FTL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04216 | Ferroptosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04978 | Mineral absorption - Homo sapiens (human) |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-199992 | trans-Golgi Network Vesicle Budding |
| reactome | R-HSA-2173782 | Binding and Uptake of Ligands by Scavenger Receptors |
| reactome | R-HSA-3000480 | Scavenging by Class A Receptors |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-421837 | Clathrin derived vesicle budding |
| reactome | R-HSA-432722 | Golgi Associated Vesicle Biogenesis |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-917937 | Iron uptake and transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FTL
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