Summary: This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008].

ferritin light chainMIM:134790Ensembl:ENSG00000087086HGNC:HGNC:3999PA2841219q13.33

GO terms in FTL

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0008043intracellular ferritin complex
CCIDAGO:0008043intracellular ferritin complex
CCTASGO:0035578azurophil granule lumen
CCHDAGO:0070062extracellular exosome
BPIEAGO:0006826iron ion transport
BPTASGO:0006879cellular iron ion homeostasis
BPIBAGO:0006880intracellular sequestering of iron ion
BPTASGO:0043312neutrophil degranulation
BPTASGO:0055072iron ion homeostasis
MFIBAGO:0004322ferroxidase activity
MFIBAGO:0004322ferroxidase activity
MFIBAGO:0005506iron ion binding
MFIDAGO:0005506iron ion binding
MFIPIGO:0005515protein binding
MFIBAGO:0008198ferrous iron binding
MFIBAGO:0008199ferric iron binding
MFIEAGO:0008199ferric iron binding
MFIBAGO:0042802identical protein binding
MFIPIGO:0042802identical protein binding

Gene expression in normal tissue: FTL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FTL

DatabasePathway IDPathway Des.
kegghsa04216Ferroptosis - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04978Mineral absorption - Homo sapiens (human)
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-199992trans-Golgi Network Vesicle Budding
reactomeR-HSA-2173782Binding and Uptake of Ligands by Scavenger Receptors
reactomeR-HSA-3000480Scavenging by Class A Receptors
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-421837Clathrin derived vesicle budding
reactomeR-HSA-432722Golgi Associated Vesicle Biogenesis
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-917937Iron uptake and transport

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FTL