GAL3ST3
Summary: This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the 3' position of galactose in N-acetyllactosamine in both type 2 (Gal-beta-1-4GlcNAc-R) oligosaccharides and core-2-branched O-glycans, but not on type 1 or core-1-branched structures. This gene, which has also been referred to as GAL3ST2, is different from the GAL3ST2 gene located on chromosome 2 that encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 3. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| galactose-3-O-sulfotransferase 3 | MIM:608234 | Ensembl:ENSG00000175229 | HGNC:HGNC:24144 | PA134864180 | 11q13.1 |
GO terms in GAL3ST3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0032580 | Golgi cisterna membrane |
| BP | NAS | GO:0005996 | monosaccharide metabolic process |
| BP | NAS | GO:0006790 | sulfur compound metabolic process |
| BP | IEA | GO:0009247 | glycolipid biosynthetic process |
| BP | NAS | GO:0009311 | oligosaccharide metabolic process |
| BP | NAS | GO:0030166 | proteoglycan biosynthetic process |
| BP | NAS | GO:0030309 | poly-N-acetyllactosamine metabolic process |
| MF | IEA | GO:0001733 | galactosylceramide sulfotransferase activity |
| MF | NAS | GO:0030246 | carbohydrate binding |
| MF | NAS | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding |
| MF | IDA | GO:0050694 | galactose 3-O-sulfotransferase activity |
| MF | IMP | GO:0050694 | galactose 3-O-sulfotransferase activity |
| MF | NAS | GO:0050698 | proteoglycan sulfotransferase activity |
Gene expression in normal tissue: GAL3ST3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GAL3ST3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GAL3ST3
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