GAS6


Summary: This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
growth arrest specific 6MIM:600441Ensembl:ENSG00000183087HGNC:HGNC:4168PA2858213q34

GO terms in GAS6


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0001786phosphatidylserine binding
MFIDAGO:0005102signaling receptor binding
MFIPIGO:0005102signaling receptor binding
MFIDAGO:0005245voltage-gated calcium channel activity
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIDAGO:0030296protein tyrosine kinase activator activity
MFIPIGO:0030971receptor tyrosine kinase binding
MFIDAGO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process
MFIDAGO:0048018receptor ligand activity
MFIDAGO:0060090molecular adaptor activity
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCIDAGO:0005737cytoplasm
CCTASGO:0005788endoplasmic reticulum lumen
CCTASGO:0005796Golgi lumen
CCTASGO:0031093platelet alpha granule lumen
CCHDAGO:0070062extracellular exosome
BPIEAGO:0001764neuron migration
BPIDAGO:0001934positive regulation of protein phosphorylation
BPISSGO:0001934positive regulation of protein phosphorylation
BPIMPGO:0001961positive regulation of cytokine-mediated signaling pathway
BPTASGO:0002576platelet degranulation
BPISSGO:0003104positive regulation of glomerular filtration
BPIDAGO:0006468protein phosphorylation
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPIDAGO:0006909phagocytosis
BPIEAGO:0006915apoptotic process
BPTASGO:0007050cell cycle arrest
BPTASGO:0007155cell adhesion
BPIDAGO:0007165signal transduction
BPTASGO:0007165signal transduction
BPIEAGO:0007167enzyme linked receptor protein signaling pathway
BPTASGO:0008283cell proliferation
BPIEAGO:0009267cellular response to starvation
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010628positive regulation of gene expression
BPIDAGO:0010804negative regulation of tumor necrosis factor-mediated signaling pathway
BPIEAGO:0010934macrophage cytokine production
BPTASGO:0016477cell migration
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0019064fusion of virus membrane with host plasma membrane
BPIDAGO:0019079viral genome replication
BPTASGO:0030168platelet activation
BPIEAGO:0031100animal organ regeneration
BPIEAGO:0031589cell-substrate adhesion
BPISSGO:0032008positive regulation of TOR signaling
BPISSGO:0032148activation of protein kinase B activity
BPIDAGO:0032689negative regulation of interferon-gamma production
BPIDAGO:0032715negative regulation of interleukin-6 production
BPIDAGO:0032720negative regulation of tumor necrosis factor production
BPIDAGO:0032825positive regulation of natural killer cell differentiation
BPIDAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIDAGO:0033159negative regulation of protein import into nucleus, translocation
BPIDAGO:0035457cellular response to interferon-alpha
BPIDAGO:0035690cellular response to drug
BPIDAGO:0035754B cell chemotaxis
BPIEAGO:0040008regulation of growth
BPIDAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIDAGO:0043277apoptotic cell clearance
BPIDAGO:0043433negative regulation of DNA-binding transcription factor activity
BPIDAGO:0043491protein kinase B signaling
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
BPIDAGO:0045860positive regulation of protein kinase activity
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0046718viral entry into host cell
BPIDAGO:0046813receptor-mediated virion attachment to host cell
BPIDAGO:0046827positive regulation of protein export from nucleus
BPIDAGO:0048146positive regulation of fibroblast proliferation
BPIDAGO:0050711negative regulation of interleukin-1 secretion
BPIDAGO:0050766positive regulation of phagocytosis
BPTASGO:0050900leukocyte migration
BPIDAGO:0051897positive regulation of protein kinase B signaling
BPIDAGO:0061098positive regulation of protein tyrosine kinase activity
BPIDAGO:0070168negative regulation of biomineral tissue development
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPTASGO:0070527platelet aggregation
BPIDAGO:0070588calcium ion transmembrane transport
BPIDAGO:0071307cellular response to vitamin K
BPISSGO:0071333cellular response to glucose stimulus
BPIEAGO:0071363cellular response to growth factor stimulus
BPIDAGO:0072659protein localization to plasma membrane
BPISSGO:0085029extracellular matrix assembly
BPIEPGO:0097028dendritic cell differentiation
BPIDAGO:0097241hematopoietic stem cell migration to bone marrow
BPIDAGO:1900142negative regulation of oligodendrocyte apoptotic process
BPIDAGO:1900165negative regulation of interleukin-6 secretion
BPIDAGO:2000270negative regulation of fibroblast apoptotic process
BPIDAGO:2000352negative regulation of endothelial cell apoptotic process
BPIDAGO:2000510positive regulation of dendritic cell chemotaxis
BPISSGO:2000533negative regulation of renal albumin absorption
BPIDAGO:2000669negative regulation of dendritic cell apoptotic process

Gene expression in normal tissue: GAS6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GAS6


DatabasePathway IDPathway Des.
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host
pharmgkbPA145011114Warfarin Pathway, Pharmacodynamics
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-159740Gamma-carboxylation of protein precursors
reactomeR-HSA-159763Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
reactomeR-HSA-159782Removal of aminoterminal propeptides from gamma-carboxylated proteins
reactomeR-HSA-159854Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
reactomeR-HSA-159854Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
reactomeR-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activation
reactomeR-HSA-163841Gamma carboxylation, hypusine formation and arylsulfatase activation
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-8957275Post-translational protein phosphorylation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD117Docetaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GAS6

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