GAS8
Summary: This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| growth arrest specific 8 | MIM:605178 | Ensembl:ENSG00000141013 | HGNC:HGNC:4166 | PA28579 | 16q24.3 |
GO terms in GAS8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0008017 | microtubule binding |
| MF | IBA | GO:0017137 | Rab GTPase binding |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0005874 | microtubule |
| CC | IDA | GO:0005874 | microtubule |
| CC | IDA | GO:0005929 | cilium |
| CC | IDA | GO:0005930 | axoneme |
| CC | IDA | GO:0031514 | motile cilium |
| CC | ISS | GO:0031514 | motile cilium |
| CC | ISS | GO:0036064 | ciliary basal body |
| CC | IEA | GO:0036126 | sperm flagellum |
| BP | IEA | GO:0003351 | epithelial cilium movement |
| BP | IEA | GO:0007368 | determination of left/right symmetry |
| BP | IEA | GO:0007420 | brain development |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0030317 | flagellated sperm motility |
| BP | ISS | GO:0030317 | flagellated sperm motility |
| BP | IBA | GO:0034613 | cellular protein localization |
| BP | IMP | GO:0035082 | axoneme assembly |
| BP | ISS | GO:0045880 | positive regulation of smoothened signaling pathway |
| BP | IMP | GO:0060294 | cilium movement involved in cell motility |
| BP | IMP | GO:1903566 | positive regulation of protein localization to cilium |
| BP | ISS | GO:1904526 | regulation of microtubule binding |
Gene expression in normal tissue: GAS8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GAS8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-5635838 | Activation of SMO |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GAS8
CLASSFICATION
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