Summary: This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012].

GATA binding protein 6MIM:601656Ensembl:ENSG00000141448HGNC:HGNC:4174PA2858918q11.2

GO terms in GATA6

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001889liver development
BPIMPGO:0003148outflow tract septum morphogenesis
BPIEAGO:0003309type B pancreatic cell differentiation
BPIEAGO:0003310pancreatic A cell differentiation
BPIDAGO:0006366transcription by RNA polymerase II
BPIEAGO:0006644phospholipid metabolic process
BPIEAGO:0007493endodermal cell fate determination
BPIBAGO:0007507heart development
BPTASGO:0007596blood coagulation
BPIEPGO:0008584male gonad development
BPIBAGO:0009887animal organ morphogenesis
BPIBAGO:0009888tissue development
BPIEAGO:0014898cardiac muscle hypertrophy in response to stress
BPIBAGO:0030513positive regulation of BMP signaling pathway
BPIMPGO:0032911negative regulation of transforming growth factor beta1 production
BPIMPGO:0032912negative regulation of transforming growth factor beta2 production
BPIEAGO:0035239tube morphogenesis
BPIMPGO:0042493response to drug
BPIMPGO:0043066negative regulation of apoptotic process
BPIEAGO:0043627response to estrogen
BPTASGO:0044267cellular protein metabolic process
BPIBAGO:0045165cell fate commitment
BPIDAGO:0045766positive regulation of angiogenesis
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0048468cell development
BPIBAGO:0048565digestive tract development
BPIEAGO:0048645animal organ formation
BPIBAGO:0048646anatomical structure formation involved in morphogenesis
BPIMPGO:0051145smooth muscle cell differentiation
BPIEAGO:0051891positive regulation of cardioblast differentiation
BPIEAGO:0055007cardiac muscle cell differentiation
BPIEAGO:0060045positive regulation of cardiac muscle cell proliferation
BPIEAGO:0060430lung saccule development
BPIEAGO:0060486Clara cell differentiation
BPIEAGO:0060510type II pneumocyte differentiation
BPIDAGO:0060575intestinal epithelial cell differentiation
BPIMPGO:0060947cardiac vascular smooth muscle cell differentiation
BPIDAGO:0070848response to growth factor
BPIDAGO:0071158positive regulation of cell cycle arrest
BPIEAGO:0071371cellular response to gonadotropin stimulus
BPIDAGO:0071456cellular response to hypoxia
BPIEAGO:0071773cellular response to BMP stimulus
BPIDAGO:0110024positive regulation of cardiac muscle myoblast proliferation
CCIDAGO:0031965nuclear membrane
MFIBAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIMPGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0001103RNA polymerase II repressing transcription factor binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIEAGO:0008270zinc ion binding
MFIPIGO:0019901protein kinase binding
MFIDAGO:0044212transcription regulatory region DNA binding

Gene expression in normal tissue: GATA6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GATA6

DatabasePathway IDPathway Des.
wikipathwaysWP1591Heart Development
wikipathwaysWP2853Endoderm Differentiation
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP3382POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
pidhes_heypathwayNotch-mediated HES/HEY network
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5683826Surfactant metabolism
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GATA6