GEMIN2
Summary: This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| gem nuclear organelle associated protein 2 | MIM:602595 | Ensembl:ENSG00000092208 | HGNC:HGNC:10884 | PA35784 | 14q21.1 |
GO terms in GEMIN2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000245 | spliceosomal complex assembly |
| BP | TAS | GO:0000375 | RNA splicing, via transesterification reactions |
| BP | IBA | GO:0000387 | spliceosomal snRNP assembly |
| BP | IDA | GO:0000387 | spliceosomal snRNP assembly |
| BP | TAS | GO:0000387 | spliceosomal snRNP assembly |
| BP | TAS | GO:0006397 | mRNA processing |
| BP | TAS | GO:0008380 | RNA splicing |
| BP | TAS | GO:0051170 | import into nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005681 | spliceosomal complex |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IBA | GO:0032797 | SMN complex |
| CC | IDA | GO:0032797 | SMN complex |
| CC | IDA | GO:0034719 | SMN-Sm protein complex |
| CC | IDA | GO:0097504 | Gemini of coiled bodies |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: GEMIN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GEMIN2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-191859 | snRNP Assembly |
| reactome | R-HSA-194441 | Metabolism of non-coding RNA |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GEMIN2
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