GLRX3


Summary: This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glutaredoxin 3MIM:612754Ensembl:ENSG00000108010HGNC:HGNC:15987PA16238982910q26.3

GO terms in GLRX3


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0002026regulation of the force of heart contraction
BPISSGO:0010614negative regulation of cardiac muscle hypertrophy
BPIEAGO:0022900electron transport chain
BPIDAGO:0044571[2Fe-2S] cluster assembly
BPIEAGO:0045454cell redox homeostasis
BPIDAGO:0097428protein maturation by iron-sulfur cluster transfer
CCIEAGO:0005634nucleus
CCIEAGO:0005829cytosol
CCIEAGO:0005938cell cortex
CCIEAGO:0030018Z disc
CCIEAGO:0030425dendrite
MFHDAGO:0003723RNA binding
MFIEAGO:0005080protein kinase C binding
MFIPIGO:0005515protein binding
MFIEAGO:0009055electron transfer activity
MFIEAGO:0015035protein disulfide oxidoreductase activity
MFIPIGO:0042802identical protein binding
MFIEAGO:0046872metal ion binding
MFIEAGO:0051536iron-sulfur cluster binding

Gene expression in normal tissue: GLRX3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GLRX3


DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-917937Iron uptake and transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GLRX3

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