Summary: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011].

geminin, DNA replication inhibitorMIM:602842Ensembl:ENSG00000112312HGNC:HGNC:17493PA384556p22.3

GO terms in GMNN

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0003682chromatin binding
MFIEAGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFIPIGO:0042826histone deacetylase binding
MFIEAGO:0070491repressing transcription factor binding
BPTASGO:0000082G1/S transition of mitotic cell cycle
BPIDAGO:0008156negative regulation of DNA replication
BPIEAGO:0009887animal organ morphogenesis
BPIDAGO:0035563positive regulation of chromatin binding
BPIDAGO:0045786negative regulation of cell cycle
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0071163DNA replication preinitiation complex assembly
BPIDAGO:2000104negative regulation of DNA-dependent DNA replication

Gene expression in normal tissue: GMNN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GMNN

DatabasePathway IDPathway Des.
wikipathwaysWP466DNA Replication
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-68827CDT1 association with the CDC6:ORC:origin complex
reactomeR-HSA-68867Assembly of the pre-replicative complex
reactomeR-HSA-68874M/G1 Transition
reactomeR-HSA-68962Activation of the pre-replicative complex
reactomeR-HSA-69002DNA Replication Pre-Initiation
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GMNN