GMNN
Summary: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| geminin, DNA replication inhibitor | MIM:602842 | Ensembl:ENSG00000112312 | HGNC:HGNC:17493 | PA38455 | 6p22.3 |
GO terms in GMNN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IEA | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IEA | GO:0070491 | repressing transcription factor binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IDA | GO:0008156 | negative regulation of DNA replication |
| BP | IEA | GO:0009887 | animal organ morphogenesis |
| BP | IDA | GO:0035563 | positive regulation of chromatin binding |
| BP | IDA | GO:0045786 | negative regulation of cell cycle |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0071163 | DNA replication preinitiation complex assembly |
| BP | IDA | GO:2000104 | negative regulation of DNA-dependent DNA replication |
Gene expression in normal tissue: GMNN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GMNN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP466 | DNA Replication |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-68827 | CDT1 association with the CDC6:ORC:origin complex |
| reactome | R-HSA-68867 | Assembly of the pre-replicative complex |
| reactome | R-HSA-68874 | M/G1 Transition |
| reactome | R-HSA-68962 | Activation of the pre-replicative complex |
| reactome | R-HSA-69002 | DNA Replication Pre-Initiation |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GMNN
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.