GNG5


Summary: G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of GTP for GDP that is bound to the alpha subunit. The alpha-GTP complex dissociates from the beta-gamma heterodimer so that the subunits, in turn, may interact with and regulate effector molecules (Gilman, 1987 [PubMed 3113327]; summary by Ahmad et al., 1995) [PubMed 7606925].[supplied by OMIM, Nov 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G protein subunit gamma 5MIM:600874Ensembl:ENSG00000174021HGNC:HGNC:4408PA287871p22.3

GO terms in GNG5


Term TypeEvidence TypeGO Term IDGO Des.
BPNASGO:0007165signal transduction
BPNASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0072513positive regulation of secondary heart field cardioblast proliferation
BPIEAGO:0072513positive regulation of secondary heart field cardioblast proliferation
BPIBAGO:2000179positive regulation of neural precursor cell proliferation
BPIEAGO:2000179positive regulation of neural precursor cell proliferation
CCIBAGO:0005834heterotrimeric G-protein complex
CCNASGO:0005834heterotrimeric G-protein complex
CCTASGO:0005886plasma membrane
CCHDAGO:0016020membrane
CCIBAGO:0031680G-protein beta/gamma-subunit complex
CCHDAGO:0070062extracellular exosome
MFNASGO:0003924GTPase activity
MFIBAGO:0005515protein binding
MFIPIGO:0005515protein binding
MFIBAGO:0030165PDZ domain binding
MFIDAGO:0030165PDZ domain binding

Gene expression in normal tissue: GNG5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GNG5


DatabasePathway IDPathway Des.
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04727GABAergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa05032Morphine addiction - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1296041Activation of G protein gated Potassium channels
reactomeR-HSA-1296059G protein gated Potassium channels
reactomeR-HSA-1296065Inwardly rectifying K+ channels
reactomeR-HSA-1296071Potassium Channels
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163359Glucagon signaling in metabolic regulation
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-202040G-protein activation
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373080Class B/2 (Secretin family receptors)
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-381676Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-390466Chaperonin-mediated protein folding
reactomeR-HSA-391251Protein folding
reactomeR-HSA-392170ADP signalling through P2Y purinoceptor 12
reactomeR-HSA-392451G beta:gamma signalling through PI3Kgamma
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392518Signal amplification
reactomeR-HSA-392518Signal amplification
reactomeR-HSA-392851Prostacyclin signalling through prostacyclin receptor
reactomeR-HSA-392851Prostacyclin signalling through prostacyclin receptor
reactomeR-HSA-397795G-protein beta:gamma signalling
reactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretion
reactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretion
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-418217G beta:gamma signalling through PLC beta
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418346Platelet homeostasis
reactomeR-HSA-418555G alpha (s) signalling events
reactomeR-HSA-418592ADP signalling through P2Y purinoceptor 1
reactomeR-HSA-418592ADP signalling through P2Y purinoceptor 1
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418597G alpha (z) signalling events
reactomeR-HSA-420092Glucagon-type ligand receptors
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-428930Thromboxane signalling through TP receptor
reactomeR-HSA-432040Vasopressin regulates renal water homeostasis via Aquaporins
reactomeR-HSA-445717Aquaporin-mediated transport
reactomeR-HSA-451326Activation of kainate receptors upon glutamate binding
reactomeR-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)
reactomeR-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)
reactomeR-HSA-500657Presynaptic function of Kainate receptors
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-6814122Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-977443GABA receptor activation
reactomeR-HSA-977444GABA B receptor activation
reactomeR-HSA-991365Activation of GABAB receptors
reactomeR-HSA-997272Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GNG5

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