GPAT3


Summary: This gene encodes a member of the lysophosphatidic acid acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glycerol-3-phosphate acyltransferase 3MIM:610958Ensembl:ENSG00000138678HGNC:HGNC:28157PA1623758884q21.23

GO terms in GPAT3


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006654phosphatidic acid biosynthetic process
BPIEAGO:0016024CDP-diacylglycerol biosynthetic process
BPIDAGO:0019432triglyceride biosynthetic process
BPIEAGO:0019432triglyceride biosynthetic process
BPIDAGO:0032006regulation of TOR signaling
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005789endoplasmic reticulum membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0016021integral component of membrane
MFTASGO:00038411-acylglycerol-3-phosphate O-acyltransferase activity
MFIDAGO:0004366glycerol-3-phosphate O-acyltransferase activity
MFIEAGO:0102420sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity

Gene expression in normal tissue: GPAT3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GPAT3


DatabasePathway IDPathway Des.
humancycPWY-5667CDP-diacylglycerol biosynthesis
humancycTRIGLSYN-PWYtriacylglycerol biosynthesis
kegghsa00561Glycerolipid metabolism - Homo sapiens (human)
kegghsa00564Glycerophospholipid metabolism - Homo sapiens (human)
wikipathwaysWP2456HIF1A and PPARG regulation of glycolysis
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483166Synthesis of PA
reactomeR-HSA-1483206Glycerophospholipid biosynthesis
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012
iGMDRD30917AAG2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GPAT3

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