GPC2
Summary:
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
glypican 2 | Ensembl:ENSG00000213420 | HGNC:HGNC:4450 | PA28831 | 7q22.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in GPC2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IEA | GO:0005615 | extracellular space |
CC | IDA | GO:0005783 | endoplasmic reticulum |
CC | TAS | GO:0005796 | Golgi lumen |
CC | TAS | GO:0005886 | plasma membrane |
CC | TAS | GO:0043202 | lysosomal lumen |
CC | IEA | GO:0046658 | anchored component of plasma membrane |
CC | IEA | GO:0062023 | collagen-containing extracellular matrix |
BP | TAS | GO:0001523 | retinoid metabolic process |
BP | TAS | GO:0006024 | glycosaminoglycan biosynthetic process |
BP | TAS | GO:0006027 | glycosaminoglycan catabolic process |
BP | IEA | GO:0007224 | smoothened signaling pathway |
BP | IEA | GO:0009966 | regulation of signal transduction |
BP | IEA | GO:0030182 | neuron differentiation |
MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: GPC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPC2
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | glypican_2pathway | Glypican 2 network |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
reactome | R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism |
reactome | R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism |
reactome | R-HSA-1643685 | Disease |
reactome | R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism |
reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
reactome | R-HSA-1971475 | A tetrasaccharide linker sequence is required for GAG synthesis |
reactome | R-HSA-2022928 | HS-GAG biosynthesis |
reactome | R-HSA-2022928 | HS-GAG biosynthesis |
reactome | R-HSA-2024096 | HS-GAG degradation |
reactome | R-HSA-2187338 | Visual phototransduction |
reactome | R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism |
reactome | R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type |
reactome | R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD |
reactome | R-HSA-3656237 | Defective EXT2 causes exostoses 2 |
reactome | R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
reactome | R-HSA-372790 | Signaling by GPCR |
reactome | R-HSA-3781865 | Diseases of glycosylation |
reactome | R-HSA-388396 | GPCR downstream signalling |
reactome | R-HSA-418594 | G alpha (i) signalling events |
reactome | R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
reactome | R-HSA-6806667 | Metabolism of fat-soluble vitamins |
reactome | R-HSA-71387 | Metabolism of carbohydrates |
reactome | R-HSA-71387 | Metabolism of carbohydrates |
reactome | R-HSA-975634 | Retinoid metabolism and transport |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPC2