GPD2
Summary: The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
glycerol-3-phosphate dehydrogenase 2 | MIM:138430 | Ensembl:ENSG00000115159 | HGNC:HGNC:4456 | PA28837 | 2q24.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in GPD2
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0004368 | glycerol-3-phosphate dehydrogenase (quinone) activity |
MF | IEA | GO:0005509 | calcium ion binding |
MF | IEA | GO:0052591 | sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity |
CC | TAS | GO:0005743 | mitochondrial inner membrane |
CC | IEA | GO:0009331 | glycerol-3-phosphate dehydrogenase complex |
BP | IEA | GO:0006094 | gluconeogenesis |
BP | TAS | GO:0006127 | glycerophosphate shuttle |
BP | IEA | GO:0019563 | glycerol catabolic process |
BP | IEA | GO:0035264 | multicellular organism growth |
BP | IEA | GO:0043010 | camera-type eye development |
Gene expression in normal tissue: GPD2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPD2
Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-1483166 | Synthesis of PA |
reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
reactome | R-HSA-1483257 | Phospholipid metabolism |
reactome | R-HSA-163560 | Triglyceride catabolism |
reactome | R-HSA-556833 | Metabolism of lipids |
reactome | R-HSA-8979227 | Triglyceride metabolism |
smpdb | SMP00025 | Phospholipid Biosynthesis |
smpdb | SMP00039 | Glycerolipid Metabolism |
smpdb | SMP00124 | Glycerol Phosphate Shuttle |
smpdb | SMP00187 | Glycerol Kinase Deficiency |
smpdb | SMP00355 | Mitochondrial Electron Transport Chain |
smpdb | SMP00529 | D-glyceric acidura |
smpdb | SMP00530 | Familial lipoprotein lipase deficiency |
wikipathways | WP143 | Fatty Acid Beta Oxidation |
wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
humancyc | PWY-4261 | glycerol degradation |
humancyc | PWY-6118 | glycerol-3-phosphate shuttle |
kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in GPD2