Summary: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

glycoprotein nmbMIM:604368Ensembl:ENSG00000136235HGNC:HGNC:4462PA288457p15.3

GO terms in GPNMB

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005178integrin binding
MFIPIGO:0005515protein binding
MFIDAGO:0008201heparin binding
MFNASGO:0042056chemoattractant activity
MFIPIGO:0045545syndecan binding
MFIMPGO:0048018receptor ligand activity
BPIEAGO:0001649osteoblast differentiation
BPIDAGO:0001818negative regulation of cytokine production
BPIDAGO:0001934positive regulation of protein phosphorylation
BPIBAGO:0007155cell adhesion
BPIEAGO:0007155cell adhesion
BPIMPGO:0007165signal transduction
BPIMPGO:0007267cell-cell signaling
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0030282bone mineralization
BPIDAGO:0030335positive regulation of cell migration
BPIDAGO:0031954positive regulation of protein autophosphorylation
BPIEAGO:0032720negative regulation of tumor necrosis factor production
BPIDAGO:0034103regulation of tissue remodeling
BPIDAGO:0042130negative regulation of T cell proliferation
BPNASGO:0045765regulation of angiogenesis
BPIMPGO:0050868negative regulation of T cell activation
BPNASGO:0050918positive chemotaxis
BPICGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIGIGO:1901215negative regulation of neuron death
BPIDAGO:2000134negative regulation of G1/S transition of mitotic cell cycle
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0016021integral component of membrane

Gene expression in normal tissue: GPNMB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GPNMB

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-8848021Signaling by PTK6
reactomeR-HSA-8857538PTK6 promotes HIF1A stabilization
reactomeR-HSA-9006927Signaling by Non-Receptor Tyrosine Kinases

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GPNMB