GPNMB
Summary: The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glycoprotein nmb | MIM:604368 | Ensembl:ENSG00000136235 | HGNC:HGNC:4462 | PA28845 | 7p15.3 |
GO terms in GPNMB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008201 | heparin binding |
| MF | NAS | GO:0042056 | chemoattractant activity |
| MF | IPI | GO:0045545 | syndecan binding |
| MF | IMP | GO:0048018 | receptor ligand activity |
| BP | IEA | GO:0001649 | osteoblast differentiation |
| BP | IDA | GO:0001818 | negative regulation of cytokine production |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IBA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IMP | GO:0007165 | signal transduction |
| BP | IMP | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0030282 | bone mineralization |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0031954 | positive regulation of protein autophosphorylation |
| BP | IEA | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IDA | GO:0034103 | regulation of tissue remodeling |
| BP | IDA | GO:0042130 | negative regulation of T cell proliferation |
| BP | NAS | GO:0045765 | regulation of angiogenesis |
| BP | IMP | GO:0050868 | negative regulation of T cell activation |
| BP | NAS | GO:0050918 | positive chemotaxis |
| BP | IC | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IGI | GO:1901215 | negative regulation of neuron death |
| BP | IDA | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0042470 | melanosome |
Gene expression in normal tissue: GPNMB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPNMB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8857538 | PTK6 promotes HIF1A stabilization |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPNMB
CLASSFICATION
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