GPRASP1


Summary: This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degradation in lysosomes. The receptors interacting with this sorting protein include D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CB1R). Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G protein-coupled receptor associated sorting protein 1MIM:300417Ensembl:ENSG00000198932HGNC:HGNC:24834PA134970616Xq22.1

GO terms in GPRASP1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005829cytosol
BPIMPGO:0008333endosome to lysosome transport
BPIMPGO:1990172G-protein coupled receptor catabolic process
BPIPIGO:1990172G-protein coupled receptor catabolic process
MFIPIGO:0005515protein binding

Gene expression in normal tissue: GPRASP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GPRASP1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GPRASP1

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