GPRC5B


Summary: This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G protein-coupled receptor class C group 5 member BMIM:605948Ensembl:ENSG00000167191HGNC:HGNC:13308PA2893816p12.3

GO terms in GPRC5B


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCIDAGO:0005730nucleolus
CCIDAGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCISSGO:0009986cell surface
CCIEAGO:0016021integral component of membrane
CCIEAGO:0030659cytoplasmic vesicle membrane
CCIDAGO:0043231intracellular membrane-bounded organelle
CCHDAGO:0070062extracellular exosome
CCIDAGO:0070062extracellular exosome
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0032147activation of protein kinase activity
BPISSGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPISSGO:0045666positive regulation of neuron differentiation
BPISSGO:0050729positive regulation of inflammatory response
BPISSGO:0060907positive regulation of macrophage cytokine production
BPISSGO:0061098positive regulation of protein tyrosine kinase activity
BPISSGO:0090263positive regulation of canonical Wnt signaling pathway
MFISSGO:0001664G-protein coupled receptor binding
MFIEAGO:0004930G-protein coupled receptor activity
MFISSGO:0019901protein kinase binding
MFIDAGO:0030295protein kinase activator activity

Gene expression in normal tissue: GPRC5B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GPRC5B


DatabasePathway IDPathway Des.
wikipathwaysWP501GPCRs, Class C Metabotropic glutamate, pheromone

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GPRC5B

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