GRAP
Summary: This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| GRB2 related adaptor protein | MIM:604330 | Ensembl:ENSG00000154016 | HGNC:HGNC:4562 | PA28958 | 17p11.2 |
GO terms in GRAP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| BP | TAS | GO:0007265 | Ras protein signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IEA | GO:0009967 | positive regulation of signal transduction |
| MF | TAS | GO:0005070 | SH3/SH2 adaptor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: GRAP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRAP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_TCR | TCR |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRAP
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