GRIA1


Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glutamate ionotropic receptor AMPA type subunit 1MIM:138248Ensembl:ENSG00000155511HGNC:HGNC:4571PA289665q33.2

GO terms in GRIA1


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0001540amyloid-beta binding
MFIBAGO:0004971AMPA glutamate receptor activity
MFIDAGO:0004971AMPA glutamate receptor activity
MFTASGO:0005231excitatory extracellular ligand-gated ion channel activity
MFIEAGO:0005234extracellularly glutamate-gated ion channel activity
MFIPIGO:0005515protein binding
MFTASGO:0008066glutamate receptor activity
MFISSGO:0030165PDZ domain binding
MFIBAGO:0099583neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
MFIEAGO:0099583neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
MFIEAGO:1904315transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
BPTASGO:0006888ER to Golgi vesicle-mediated transport
BPTASGO:0007165signal transduction
BPTASGO:0007268chemical synaptic transmission
BPIEAGO:0007616long-term memory
BPIEAGO:0031623receptor internalization
BPIEAGO:0034220ion transmembrane transport
BPIEAGO:0035235ionotropic glutamate receptor signaling pathway
BPTASGO:0048208COPII vesicle coating
BPIEAGO:0060079excitatory postsynaptic potential
BPIEAGO:0060292long term synaptic depression
BPIEAGO:0099566regulation of postsynaptic cytosolic calcium ion concentration
CCIEAGO:0000139Golgi membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0008021synaptic vesicle
CCISSGO:0009986cell surface
CCTASGO:0012507ER to Golgi transport vesicle membrane
CCISSGO:0014069postsynaptic density
CCIEAGO:0030054cell junction
CCISSGO:0030425dendrite
CCTASGO:0030666endocytic vesicle membrane
CCIEAGO:0031901early endosome membrane
CCIBAGO:0032281AMPA glutamate receptor complex
CCISSGO:0032281AMPA glutamate receptor complex
CCIDAGO:0032591dendritic spine membrane
CCTASGO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane
CCISSGO:0043025neuronal cell body
CCISSGO:0043197dendritic spine
CCIEAGO:0044308axonal spine
CCISSGO:0044309neuron spine
CCIDAGO:0055037recycling endosome
CCIEAGO:0055038recycling endosome membrane
CCIEAGO:0098839postsynaptic density membrane

Gene expression in normal tissue: GRIA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRIA1


DatabasePathway IDPathway Des.
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2447Amyotrophic lateral sclerosis (ALS)
wikipathwaysWP2636Common Pathways Underlying Drug Addiction
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
wikipathwaysWP4222Phosphodiesterases in neuronal function
netpathPathway_BDNFBDNF
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05033Nicotine addiction - Homo sapiens (human)
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-199977ER to Golgi Anterograde Transport
reactomeR-HSA-199991Membrane Trafficking
reactomeR-HSA-204005COPII-mediated vesicle transport
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-399710Activation of AMPA receptors
reactomeR-HSA-399719Trafficking of AMPA receptors
reactomeR-HSA-399721Glutamate binding, activation of AMPA receptors and synaptic plasticity
reactomeR-HSA-416993Trafficking of GluR2-containing AMPA receptors
reactomeR-HSA-438066Unblocking of NMDA receptor, glutamate binding and activation
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-5653656Vesicle-mediated transport
reactomeR-HSA-5694530Cargo concentration in the ER
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-8849932Synaptic adhesion-like molecules
reactomeR-HSA-948021Transport to the Golgi and subsequent modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRIA1

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