GRIK4
Summary: This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutamate ionotropic receptor kainate type subunit 4 | MIM:600282 | Ensembl:ENSG00000149403 | HGNC:HGNC:4582 | PA28976 | 11q23.3 |
GO terms in GRIK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007215 | glutamate receptor signaling pathway |
| BP | TAS | GO:0007268 | chemical synaptic transmission |
| BP | IEA | GO:0034220 | ion transmembrane transport |
| BP | IEA | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| BP | IBA | GO:0035249 | synaptic transmission, glutamatergic |
| BP | IBA | GO:0050804 | modulation of chemical synaptic transmission |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IBA | GO:0032983 | kainate selective glutamate receptor complex |
| CC | IEA | GO:0032983 | kainate selective glutamate receptor complex |
| CC | IBA | GO:0042734 | presynaptic membrane |
| CC | IEA | GO:0042734 | presynaptic membrane |
| CC | IBA | GO:0045211 | postsynaptic membrane |
| CC | IEA | GO:0045211 | postsynaptic membrane |
| CC | IBA | GO:0098839 | postsynaptic density membrane |
| MF | IEA | GO:0005234 | extracellularly glutamate-gated ion channel activity |
| MF | IBA | GO:0008066 | glutamate receptor activity |
| MF | TAS | GO:0015276 | ligand-gated ion channel activity |
| MF | IBA | GO:0015277 | kainate selective glutamate receptor activity |
| MF | TAS | GO:0015277 | kainate selective glutamate receptor activity |
| MF | IBA | GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential |
Gene expression in normal tissue: GRIK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRIK4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-451306 | Ionotropic activity of kainate receptors |
| reactome | R-HSA-451308 | Activation of Ca-permeable Kainate Receptor |
| reactome | R-HSA-451326 | Activation of kainate receptors upon glutamate binding |
| kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRIK4
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