GSTO1
Summary: The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glutathione S-transferase omega 1 | MIM:605482 | Ensembl:ENSG00000148834 | HGNC:HGNC:13312 | PA133787054 | 10q25.1 |
GO terms in GSTO1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004364 | glutathione transferase activity |
| MF | TAS | GO:0004364 | glutathione transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0016491 | oxidoreductase activity |
| MF | IBA | GO:0045174 | glutathione dehydrogenase (ascorbate) activity |
| MF | IDA | GO:0045174 | glutathione dehydrogenase (ascorbate) activity |
| MF | TAS | GO:0050610 | methylarsonate reductase activity |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IDA | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| BP | IC | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| BP | IC | GO:0014810 | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| BP | IDA | GO:0019852 | L-ascorbic acid metabolic process |
| BP | TAS | GO:0032259 | methylation |
| BP | TAS | GO:0035722 | interleukin-12-mediated signaling pathway |
| BP | IDA | GO:0042178 | xenobiotic catabolic process |
| BP | IBA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IDA | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity |
| BP | IDA | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity |
| BP | IDA | GO:0071243 | cellular response to arsenic-containing substance |
| BP | IEA | GO:0098869 | cellular oxidant detoxification |
| BP | TAS | GO:1901687 | glutathione derivative biosynthetic process |
Gene expression in normal tissue: GSTO1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GSTO1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-156580 | Phase II - Conjugation of compounds |
| reactome | R-HSA-156581 | Methylation |
| reactome | R-HSA-156590 | Glutathione conjugation |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-196836 | Vitamin C (ascorbate) metabolism |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-447115 | Interleukin-12 family signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-8950505 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| reactome | R-HSA-9020591 | Interleukin-12 signaling |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP4100 | Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation |
| wikipathways | WP702 | Metapathway biotransformation Phase I and II |
| humancyc | PWY-4202 | arsenate detoxification I (glutaredoxin) |
| humancyc | PWY-6370 | ascorbate recycling (cytosolic) |
| kegg | hsa00480 | Glutathione metabolism - Homo sapiens (human) |
| kegg | hsa00980 | Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00982 | Drug metabolism - cytochrome P450 - Homo sapiens (human) |
| kegg | hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GSTO1
CLASSFICATION
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