Summary: This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

host cell factor C1MIM:300019Ensembl:ENSG00000172534HGNC:HGNC:4839PA29215Xq28

GO terms in HCFC1

Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0000123histone acetyltransferase complex
CCIDAGO:0005671Ada2/Gcn5/Ada3 transcription activator complex
CCIDAGO:0032991protein-containing complex
CCIDAGO:0043025neuronal cell body
CCIDAGO:0048188Set1C/COMPASS complex
CCIDAGO:0070461SAGA-type complex
CCIDAGO:0071339MLL1 complex
BPISSGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0007005mitochondrion organization
BPIEAGO:0007049cell cycle
BPIDAGO:0010628positive regulation of gene expression
BPTASGO:0016579protein deubiquitination
BPNASGO:0019046release from viral latency
BPIDAGO:0043254regulation of protein complex assembly
BPIDAGO:0043981histone H4-K5 acetylation
BPIDAGO:0043982histone H4-K8 acetylation
BPIDAGO:0043984histone H4-K16 acetylation
BPTASGO:0045787positive regulation of cell cycle
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0050821protein stabilization
BPIEAGO:0071407cellular response to organic cyclic compound
MFIEAGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MFIDAGO:0003682chromatin binding
MFNASGO:0003700DNA-binding transcription factor activity
MFIMPGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIPIGO:0030674protein binding, bridging
MFIPIGO:0033613activating transcription factor binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0043995histone acetyltransferase activity (H4-K5 specific)
MFIDAGO:0043996histone acetyltransferase activity (H4-K8 specific)
MFHDAGO:0045296cadherin binding
MFIDAGO:0046972histone acetyltransferase activity (H4-K16 specific)

Gene expression in normal tissue: HCFC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HCFC1

DatabasePathway IDPathway Des.
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-2151201Transcriptional activation of mitochondrial biogenesis
reactomeR-HSA-3214847HATs acetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5689603UCH proteinases
reactomeR-HSA-597592Post-translational protein modification
kegghsa05168Herpes simplex infection - Homo sapiens (human)
wikipathwaysWP391Mitochondrial Gene Expression

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HCFC1