HCFC1
Summary: This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| host cell factor C1 | MIM:300019 | Ensembl:ENSG00000172534 | HGNC:HGNC:4839 | PA29215 | Xq28 |
GO terms in HCFC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000123 | histone acetyltransferase complex |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0030424 | axon |
| CC | IEA | GO:0030425 | dendrite |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0043025 | neuronal cell body |
| CC | IDA | GO:0048188 | Set1C/COMPASS complex |
| CC | IDA | GO:0070461 | SAGA-type complex |
| CC | IDA | GO:0071339 | MLL1 complex |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007005 | mitochondrion organization |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | NAS | GO:0019046 | release from viral latency |
| BP | IDA | GO:0043254 | regulation of protein complex assembly |
| BP | IDA | GO:0043981 | histone H4-K5 acetylation |
| BP | IDA | GO:0043982 | histone H4-K8 acetylation |
| BP | IDA | GO:0043984 | histone H4-K16 acetylation |
| BP | TAS | GO:0045787 | positive regulation of cell cycle |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0050821 | protein stabilization |
| BP | IEA | GO:0071407 | cellular response to organic cyclic compound |
| MF | IEA | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IMP | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0030674 | protein binding, bridging |
| MF | IPI | GO:0033613 | activating transcription factor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0043995 | histone acetyltransferase activity (H4-K5 specific) |
| MF | IDA | GO:0043996 | histone acetyltransferase activity (H4-K8 specific) |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IDA | GO:0046972 | histone acetyltransferase activity (H4-K16 specific) |
Gene expression in normal tissue: HCFC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HCFC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis |
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689603 | UCH proteinases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| wikipathways | WP391 | Mitochondrial Gene Expression |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HCFC1
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.