Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008].

histone deacetylase 9MIM:606543Ensembl:ENSG00000048052HGNC:HGNC:14065PA383777p21.1

GO terms in HDAC9

Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0003714transcription corepressor activity
MFIDAGO:0004407histone deacetylase activity
MFIPIGO:0005080protein kinase C binding
MFIPIGO:0005515protein binding
MFIDAGO:0008134transcription factor binding
MFIPIGO:0008134transcription factor binding
MFIEAGO:0032041NAD-dependent histone deacetylase activity (H3-K14 specific)
MFIDAGO:0033558protein deacetylase activity
MFIPIGO:0042826histone deacetylase binding
MFIEAGO:0046872metal ion binding
MFIDAGO:0070491repressing transcription factor binding
MFIPIGO:0070491repressing transcription factor binding
MFISSGO:0070491repressing transcription factor binding
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0001975response to amphetamine
BPIEAGO:0006351transcription, DNA-templated
BPTASGO:0006954inflammatory response
BPISSGO:0007507heart development
BPIDAGO:0016575histone deacetylation
BPIEAGO:0030182neuron differentiation
BPTASGO:0030183B cell differentiation
BPIDAGO:0032869cellular response to insulin stimulus
BPIDAGO:0034983peptidyl-lysine deacetylation
BPTASGO:0042113B cell activation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPISSGO:0048742regulation of skeletal muscle fiber development
BPISSGO:0051153regulation of striated muscle cell differentiation
BPIDAGO:0070932histone H3 deacetylation
BPIDAGO:0070933histone H4 deacetylation
BPIMPGO:0090050positive regulation of cell migration involved in sprouting angiogenesis
CCTASGO:0000118histone deacetylase complex
CCIDAGO:0005667transcription factor complex
CCISSGO:0035097histone methyltransferase complex

Gene expression in normal tissue: HDAC9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HDAC9

DatabasePathway IDPathway Des.
biocartamitrpathwaysignal dependent regulation of myogenesis by corepressor mitr
biocartanfatpathwaynfat and hypertrophy of the heart
biocartaranbp2pathwaysumoylation by ranbp2 regulates transcriptional repression
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactomeR-HSA-2644603Signaling by NOTCH1 in Cancer
reactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactomeR-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactomeR-HSA-5663202Diseases of signal transduction
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP3414Initiation of transcription and translation elongation at the HIV-1 LTR
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3996Ethanol effects on histone modifications
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
pharmgkbPA165959313Valproic Acid Pathway, Pharmacodynamics
pidhdac_classii_pathwaySignaling events mediated by HDAC Class II
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HDAC9