Summary: HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008].

major histocompatibility complex, class II, DO alphaMIM:142930Ensembl:ENSG00000204252HGNC:HGNC:4936PA350606p21.32

GO terms in HLA-DOA

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005765lysosomal membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0010008endosome membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0042613MHC class II protein complex
BPIDAGO:0002587negative regulation of antigen processing and presentation of peptide antigen via MHC class II
BPIEAGO:0006955immune response
BPIEAGO:0007165signal transduction
BPTASGO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
BPIEAGO:0045580regulation of T cell differentiation
MFIPIGO:0005515protein binding
MFIDAGO:0023026MHC class II protein complex binding
MFTASGO:0032395MHC class II receptor activity

Gene expression in normal tissue: HLA-DOA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HLA-DOA

DatabasePathway IDPathway Des.
wikipathwaysWP2328Allograft Rejection
kegghsa04145Phagosome - Homo sapiens (human)
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04612Antigen processing and presentation - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04672Intestinal immune network for IgA production - Homo sapiens (human)
kegghsa04940Type I diabetes mellitus - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05150Staphylococcus aureus infection - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05310Asthma - Homo sapiens (human)
kegghsa05320Autoimmune thyroid disease - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
kegghsa05330Allograft rejection - Homo sapiens (human)
kegghsa05332Graft-versus-host disease - Homo sapiens (human)
kegghsa05416Viral myocarditis - Homo sapiens (human)
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-2132295MHC class II antigen presentation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HLA-DOA