HMGCLL1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 | Ensembl:ENSG00000146151 | HGNC:HGNC:21359 | PA134989971 | 6p12.1 |
GO terms in HMGCLL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016020 | membrane |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IBA | GO:0006552 | leucine catabolic process |
| BP | IBA | GO:0006629 | lipid metabolic process |
| BP | IBA | GO:0046951 | ketone body biosynthetic process |
| BP | IDA | GO:0046951 | ketone body biosynthetic process |
| BP | TAS | GO:0046951 | ketone body biosynthetic process |
| MF | IBA | GO:0004419 | hydroxymethylglutaryl-CoA lyase activity |
| MF | IDA | GO:0004419 | hydroxymethylglutaryl-CoA lyase activity |
| MF | ISS | GO:0004419 | hydroxymethylglutaryl-CoA lyase activity |
| MF | TAS | GO:0004419 | hydroxymethylglutaryl-CoA lyase activity |
| MF | ISS | GO:0046872 | metal ion binding |
| MF | TAS | GO:0046872 | metal ion binding |
Gene expression in normal tissue: HMGCLL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HMGCLL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-74182 | Ketone body metabolism |
| reactome | R-HSA-77111 | Synthesis of Ketone Bodies |
| kegg | hsa00072 | Synthesis and degradation of ketone bodies - Homo sapiens (human) |
| kegg | hsa00280 | Valine, leucine and isoleucine degradation - Homo sapiens (human) |
| kegg | hsa00650 | Butanoate metabolism - Homo sapiens (human) |
| kegg | hsa04146 | Peroxisome - Homo sapiens (human) |
| humancyc | LEU-DEG2-PWY | leucine degradation |
| humancyc | PWY66-367 | ketogenesis |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HMGCLL1
CLASSFICATION
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