Summary: The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013].

hydroxysteroid 17-beta dehydrogenase 6MIM:606623Ensembl:ENSG00000025423HGNC:HGNC:23316PA14267167112q13.3

GO terms in HSD17B6

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003824catalytic activity
MFIEAGO:0004303estradiol 17-beta-dehydrogenase activity
MFIEAGO:0004745retinol dehydrogenase activity
MFTASGO:0009055electron transfer activity
MFNASGO:0016491oxidoreductase activity
MFIEAGO:0047035testosterone dehydrogenase (NAD+) activity
BPNASGO:0006702androgen biosynthetic process
BPTASGO:0006710androgen catabolic process
BPIEAGO:0022900electron transport chain
CCIEAGO:0005783endoplasmic reticulum
CCIEAGO:0031901early endosome membrane

Gene expression in normal tissue: HSD17B6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSD17B6

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2453902The canonical retinoid cycle in rods (twilight vision)
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
kegghsa00140Steroid hormone biosynthesis - Homo sapiens (human)
kegghsa00830Retinol metabolism - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSD17B6