HSD17B6
Summary: The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| hydroxysteroid 17-beta dehydrogenase 6 | MIM:606623 | Ensembl:ENSG00000025423 | HGNC:HGNC:23316 | PA142671671 | 12q13.3 |
GO terms in HSD17B6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003824 | catalytic activity |
| MF | IEA | GO:0004303 | estradiol 17-beta-dehydrogenase activity |
| MF | IEA | GO:0004745 | retinol dehydrogenase activity |
| MF | TAS | GO:0009055 | electron transfer activity |
| MF | NAS | GO:0016491 | oxidoreductase activity |
| MF | IEA | GO:0047035 | testosterone dehydrogenase (NAD+) activity |
| BP | NAS | GO:0006702 | androgen biosynthetic process |
| BP | TAS | GO:0006710 | androgen catabolic process |
| BP | IEA | GO:0022900 | electron transport chain |
| CC | NAS | GO:0005622 | intracellular |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IEA | GO:0031901 | early endosome membrane |
Gene expression in normal tissue: HSD17B6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSD17B6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-2453902 | The canonical retinoid cycle in rods (twilight vision) |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| kegg | hsa00140 | Steroid hormone biosynthesis - Homo sapiens (human) |
| kegg | hsa00830 | Retinol metabolism - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSD17B6
CLASSFICATION
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