HSF2
Summary: The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock transcription factor 2 | MIM:140581 | Ensembl:ENSG00000025156 | HGNC:HGNC:5225 | PA29494 | 6q22.31 |
GO terms in HSF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IBA | GO:0034605 | cellular response to heat |
| BP | IBA | GO:0043618 | regulation of transcription from RNA polymerase II promoter in response to stress |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0061408 | positive regulation of transcription from RNA polymerase II promoter in response to heat stress |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: HSF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSF2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | era_genomic_pathway | Validated nuclear estrogen receptor alpha network |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSF2
CLASSFICATION
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