Summary: This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013].

5-hydroxytryptamine receptor 6MIM:601109Ensembl:ENSG00000158748HGNC:HGNC:5301PA295601p36.13

GO terms in HTR6

Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BPTASGO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
BPIBAGO:0007268chemical synaptic transmission
BPTASGO:0007268chemical synaptic transmission
BPISSGO:0021795cerebral cortex cell migration
BPIDAGO:0032008positive regulation of TOR signaling
BPIEAGO:0098664G-protein coupled serotonin receptor signaling pathway
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCTASGO:0005887integral component of plasma membrane
MFIBAGO:0004930G-protein coupled receptor activity
MFTASGO:0004969histamine receptor activity
MFIBAGO:0004993G-protein coupled serotonin receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0030594neurotransmitter receptor activity

Gene expression in normal tissue: HTR6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HTR6

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375280Amine ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-390666Serotonin receptors
reactomeR-HSA-418555G alpha (s) signalling events
reactomeR-HSA-500792GPCR ligand binding
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
wikipathwaysWP58Monoamine GPCRs
wikipathwaysWP734Serotonin Receptor 4-6-7 and NR3C Signaling
smpdbSMP00312Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
pharmgkbPA161749006Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HTR6