IARS2
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of isoleucine-tRNA synthetase exist, a cytoplasmic form and a mitochondrial form. This gene encodes the mitochondrial isoleucine-tRNA synthetase which belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Dec 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| isoleucyl-tRNA synthetase 2, mitochondrial | MIM:612801 | Ensembl:ENSG00000067704 | HGNC:HGNC:29685 | PA142671670 | 1q41 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IARS2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006418 | tRNA aminoacylation for protein translation |
| BP | IBA | GO:0006428 | isoleucyl-tRNA aminoacylation |
| BP | IEA | GO:0006428 | isoleucyl-tRNA aminoacylation |
| BP | IBA | GO:0032543 | mitochondrial translation |
| BP | IEA | GO:0106074 | aminoacyl-tRNA metabolism involved in translational fidelity |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| MF | IEA | GO:0000049 | tRNA binding |
| MF | IEA | GO:0002161 | aminoacyl-tRNA editing activity |
| MF | IBA | GO:0004822 | isoleucine-tRNA ligase activity |
| MF | TAS | GO:0004822 | isoleucine-tRNA ligase activity |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: IARS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IARS2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-379724 | tRNA Aminoacylation |
| reactome | R-HSA-379726 | Mitochondrial tRNA aminoacylation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-72766 | Translation |
| humancyc | TRNA-CHARGING-PWY | tRNA charging |
| kegg | hsa00970 | Aminoacyl-tRNA biosynthesis - Homo sapiens (human) |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IARS2
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