IDE


Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
insulin degrading enzymeMIM:146680Ensembl:ENSG00000119912HGNC:HGNC:5381PA2962910q23.33

GO terms in IDE


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001540amyloid-beta binding
MFIEAGO:0001618virus receptor activity
MFIDAGO:0004222metalloendopeptidase activity
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIDAGO:0008270zinc ion binding
MFIEAGO:0016887ATPase activity
MFIEAGO:0031626beta-endorphin binding
MFIPIGO:0042277peptide binding
MFIPIGO:0042803protein homodimerization activity
MFIDAGO:0043559insulin binding
MFIPIGO:0043559insulin binding
MFIPIGO:0140036ubiquitin-dependent protein binding
CCIDAGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIBAGO:0005739mitochondrion
CCIDAGO:0005739mitochondrion
CCIDAGO:0005777peroxisome
CCIBAGO:0005782peroxisomal matrix
CCTASGO:0005782peroxisomal matrix
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCIDAGO:0009986cell surface
CCIEAGO:0031597cytosolic proteasome complex
BPIDAGO:0006508proteolysis
BPTASGO:0006625protein targeting to peroxisome
BPNASGO:0008286insulin receptor signaling pathway
BPIDAGO:0008340determination of adult lifespan
BPIDAGO:0010815bradykinin catabolic process
BPIDAGO:0010992ubiquitin recycling
BPIDAGO:0032461positive regulation of protein oligomerization
BPIBAGO:0042447hormone catabolic process
BPIEAGO:0042447hormone catabolic process
BPIBAGO:0043171peptide catabolic process
BPTASGO:0045732positive regulation of protein catabolic process
BPIEAGO:0045861negative regulation of proteolysis
BPIEAGO:0046718viral entry into host cell
BPIBAGO:0050435amyloid-beta metabolic process
BPIDAGO:0050435amyloid-beta metabolic process
BPIDAGO:0051260protein homooligomerization
BPIEAGO:0051289protein homotetramerization
BPIEAGO:0051291protein heterooligomerization
BPIBAGO:0051603proteolysis involved in cellular protein catabolic process
BPIDAGO:0051603proteolysis involved in cellular protein catabolic process
BPISSGO:0097242amyloid-beta clearance
BPIDAGO:1901142insulin metabolic process
BPIDAGO:1901143insulin catabolic process

Gene expression in normal tissue: IDE

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IDE


DatabasePathway IDPathway Des.
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-9033241Peroxisomal protein import
reactomeR-HSA-9033241Peroxisomal protein import
wikipathwaysWP2059Alzheimers Disease
kegghsa05010Alzheimer,s disease - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD30917AAG1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IDE

​​​​