Summary: The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008].

interleukin 13 receptor subunit alpha 1MIM:300119Ensembl:ENSG00000131724HGNC:HGNC:5974PA200Xq24

Gene Categories:


GO terms in IL13RA1

Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004896cytokine receptor activity
MFIEAGO:0004896cytokine receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0016515interleukin-13 receptor activity
MFIBAGO:0019955cytokine binding
CCTASGO:0005886plasma membrane
CCTASGO:0005898interleukin-13 receptor complex
CCIBAGO:0009897external side of plasma membrane
CCIBAGO:0043235receptor complex
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway

Gene expression in normal tissue: IL13RA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL13RA1

DatabasePathway IDPathway Des.
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
wikipathwaysWP3945TYROBP Causal Network
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
pidil4_2pathwayIL4-mediated signaling events

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL13RA1