IL16
Summary: The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 16 | MIM:603035 | Ensembl:ENSG00000172349 | HGNC:HGNC:5980 | PA29793 | 15q25.1 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IL16
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005125 | cytokine activity |
| MF | IPI | GO:0042609 | CD4 receptor binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006955 | immune response |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0030595 | leukocyte chemotaxis |
| BP | IEA | GO:0050930 | induction of positive chemotaxis |
| BP | IDA | GO:0051924 | regulation of calcium ion transport |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0016607 | nuclear speck |
Gene expression in normal tissue: IL16
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL16
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449836 | Other interleukin signaling |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL16
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