IL1B


Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:147720
PHARMGKB IDPA29808
Map Location2q14.1

GO terms in IL1B


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005576 extracellular region
CC NAS GO:0005576 extracellular region
CC TAS GO:0005576 extracellular region
CC IBA GO:0005615 extracellular space
CC IDA GO:0005615 extracellular space
CC IMP GO:0005615 extracellular space
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Gene expression in normal tissue: IL1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL1B


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Database
Pathway ID
Pathway Des.
biocarta il1rpathway signal transduction through il1r
biocarta nthipathway nfkb activation by nontypeable hemophilus influenzae
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
reactome R-HSA-446652 Interleukin-1 family signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD551 Ponatinib 1
iGMDRD459 RO-3306 1
iGMDRD655 SCHEMBL618594 1
iGMDRD660 GSK-1070916 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL1B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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