IL6R


Summary: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
interleukin 6 receptorMIM:147880Ensembl:ENSG00000160712HGNC:HGNC:6019PA298351q21.3

GO terms in IL6R


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004896cytokine receptor activity
MFIMPGO:0004897ciliary neurotrophic factor receptor activity
MFIDAGO:0004915interleukin-6 receptor activity
MFIPIGO:0005138interleukin-6 receptor binding
MFIBAGO:0005143interleukin-12 receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFIPIGO:0019899enzyme binding
MFIBAGO:0019955cytokine binding
MFIBAGO:0019981interleukin-6 binding
MFIPIGO:0019981interleukin-6 binding
MFIBAGO:0042164interleukin-12 alpha subunit binding
MFIPIGO:0042803protein homodimerization activity
MFIBAGO:0045519interleukin-23 receptor binding
MFIPIGO:0070119ciliary neurotrophic factor binding
BPTASGO:0002384hepatic immune response
BPICGO:0002548monocyte chemotaxis
BPTASGO:0002690positive regulation of leukocyte chemotaxis
BPIBAGO:0002827positive regulation of T-helper 1 type immune response
BPTASGO:0006953acute-phase response
BPIDAGO:0008284positive regulation of cell proliferation
BPIMPGO:0008284positive regulation of cell proliferation
BPIBAGO:0010536positive regulation of activation of Janus kinase activity
BPIDAGO:0019221cytokine-mediated signaling pathway
BPTASGO:0019221cytokine-mediated signaling pathway
BPICGO:0031018endocrine pancreas development
BPIMPGO:0031018endocrine pancreas development
BPIDAGO:0032722positive regulation of chemokine production
BPIBAGO:0032729positive regulation of interferon-gamma production
BPIDAGO:0032755positive regulation of interleukin-6 production
BPIBAGO:0032816positive regulation of natural killer cell activation
BPIDAGO:0034097response to cytokine
BPIBAGO:0042104positive regulation of activated T cell proliferation
BPIBAGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPIMPGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPTASGO:0045669positive regulation of osteoblast differentiation
BPIDAGO:0048661positive regulation of smooth muscle cell proliferation
BPIBAGO:0050671positive regulation of lymphocyte proliferation
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPTASGO:0050829defense response to Gram-negative bacterium
BPIBAGO:0051135positive regulation of NK T cell activation
BPIBAGO:0070102interleukin-6-mediated signaling pathway
BPIMPGO:0070102interleukin-6-mediated signaling pathway
BPTASGO:0070102interleukin-6-mediated signaling pathway
BPIMPGO:0070120ciliary neurotrophic factor-mediated signaling pathway
BPTASGO:0097191extrinsic apoptotic signaling pathway
CCIDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCTASGO:0005886plasma membrane
CCIBAGO:0005896interleukin-6 receptor complex
CCIDAGO:0005896interleukin-6 receptor complex
CCIBAGO:0009897external side of plasma membrane
CCIEAGO:0009986cell surface
CCIEAGO:0016323basolateral plasma membrane
CCIDAGO:0016324apical plasma membrane
CCIBAGO:0043235receptor complex
CCIBAGO:0043514interleukin-12 complex
CCIDAGO:0070110ciliary neurotrophic factor receptor complex
CCIBAGO:0070743interleukin-23 complex

Gene expression in normal tissue: IL6R

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IL6R


DatabasePathway IDPathway Des.
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartail6pathwayil 6 signaling pathway
reactomeR-HSA-1059683Interleukin-6 signaling
reactomeR-HSA-110056MAPK3 (ERK1) activation
reactomeR-HSA-112409RAF-independent MAPK1/3 activation
reactomeR-HSA-112411MAPK1 (ERK2) activation
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6783589Interleukin-6 family signaling
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP364IL-6 signaling pathway
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP615Senescence and Autophagy in Cancer
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
pidil6_7pathwayIL6-mediated signaling events
pidshp2_pathwaySHP2 signaling
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
netpathPathway_IL6IL6

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL6R

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