INPP5F
Summary: The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
inositol polyphosphate-5-phosphatase F | MIM:609389 | Ensembl:ENSG00000198825 | HGNC:HGNC:17054 | PA134927878 | 10q26.11 |
GO terms in INPP5F
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0008934 | inositol monophosphate 1-phosphatase activity |
MF | IDA | GO:0034595 | phosphatidylinositol phosphate 5-phosphatase activity |
MF | IDA | GO:0034595 | phosphatidylinositol phosphate 5-phosphatase activity |
MF | IDA | GO:0034596 | phosphatidylinositol phosphate 4-phosphatase activity |
MF | TAS | GO:0034596 | phosphatidylinositol phosphate 4-phosphatase activity |
MF | IDA | GO:0042803 | protein homodimerization activity |
MF | ISS | GO:0042803 | protein homodimerization activity |
MF | IBA | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity |
MF | IEA | GO:0052832 | inositol monophosphate 3-phosphatase activity |
MF | IEA | GO:0052833 | inositol monophosphate 4-phosphatase activity |
CC | IBA | GO:0005769 | early endosome |
CC | IDA | GO:0005769 | early endosome |
CC | IBA | GO:0005783 | endoplasmic reticulum |
CC | IDA | GO:0005905 | clathrin-coated pit |
CC | IEA | GO:0030424 | axon |
CC | IEA | GO:0030425 | dendrite |
CC | TAS | GO:0031901 | early endosome membrane |
CC | IEA | GO:0043025 | neuronal cell body |
CC | IBA | GO:0045334 | clathrin-coated endocytic vesicle |
CC | IDA | GO:0045334 | clathrin-coated endocytic vesicle |
CC | IDA | GO:0055037 | recycling endosome |
CC | ISS | GO:0055037 | recycling endosome |
BP | IDA | GO:0001921 | positive regulation of receptor recycling |
BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
BP | IEA | GO:0008344 | adult locomotory behavior |
BP | ISS | GO:0014898 | cardiac muscle hypertrophy in response to stress |
BP | ISS | GO:0031161 | phosphatidylinositol catabolic process |
BP | IEA | GO:0033137 | negative regulation of peptidyl-serine phosphorylation |
BP | IDA | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein |
BP | IBA | GO:0046856 | phosphatidylinositol dephosphorylation |
BP | IDA | GO:0046856 | phosphatidylinositol dephosphorylation |
BP | ISS | GO:0048015 | phosphatidylinositol-mediated signaling |
BP | ISS | GO:0048681 | negative regulation of axon regeneration |
BP | IEA | GO:0051896 | regulation of protein kinase B signaling |
BP | ISS | GO:0072583 | clathrin-dependent endocytosis |
BP | IMP | GO:2000145 | regulation of cell motility |
BP | IBA | GO:2001135 | regulation of endocytic recycling |
BP | IMP | GO:2001135 | regulation of endocytic recycling |
BP | ISS | GO:2001135 | regulation of endocytic recycling |
Gene expression in normal tissue: INPP5F
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INPP5F
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
humancyc | PWY-6358 | superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism |
humancyc | PWY-6363 | D-myo-inositol (1,4,5)-trisphosphate degradation |
humancyc | PWY-6368 | 3-phosphoinositide degradation |
reactome | R-HSA-1430728 | Metabolism |
reactome | R-HSA-1483255 | PI Metabolism |
reactome | R-HSA-1483257 | Phospholipid metabolism |
reactome | R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane |
reactome | R-HSA-556833 | Metabolism of lipids |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INPP5F