ITGA9


Summary: This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
integrin subunit alpha 9MIM:603963Ensembl:ENSG00000144668HGNC:HGNC:6145PA299453p22.2

Gene Categories:

DRUGGABLE GENOME

GO terms in ITGA9


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCTASGO:0008305integrin complex
CCIEAGO:0009925basal plasma membrane
CCIEAGO:0034679integrin alpha9-beta1 complex
BPIGIGO:0007155cell adhesion
BPIEAGO:0007229integrin-mediated signaling pathway
BPTASGO:0030198extracellular matrix organization
BPIEAGO:0030593neutrophil chemotaxis
BPIEAGO:0042060wound healing
MFIEAGO:0005518collagen binding
MFIEAGO:0043236laminin binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: ITGA9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ITGA9


DatabasePathway IDPathway Des.
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04512ECM-receptor interaction - Homo sapiens (human)
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
pidarf6_traffickingpathwayArf6 trafficking events
pidintegrin1_pathwayBeta1 integrin cell surface interactions
pidintegrin_a9b1_pathwayAlpha9 beta1 integrin signaling events
pidplexind1_pathwayPlexin-D1 Signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-216083Integrin cell surface interactions
reactomeR-HSA-3000178ECM proteoglycans
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445144Signal transduction by L1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD68Paclitaxel1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGA9

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