JAM2
Summary: This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| junctional adhesion molecule 2 | MIM:606870 | Ensembl:ENSG00000154721 | HGNC:HGNC:14686 | PA29992 | 21q21.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in JAM2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005923 | bicellular tight junction |
| BP | IEA | GO:0007162 | negative regulation of cell adhesion |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | NAS | GO:0098609 | cell-cell adhesion |
Gene expression in normal tissue: JAM2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in JAM2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| pid | amb2_neutrophils_pathway | amb2 Integrin signaling |
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in JAM2
CLASSFICATION
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