JAM2


Summary: This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
junctional adhesion molecule 2MIM:606870Ensembl:ENSG00000154721HGNC:HGNC:14686PA2999221q21.3

Gene Categories:

DRUGGABLE GENOME

GO terms in JAM2


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIEAGO:0046982protein heterodimerization activity
CCTASGO:0005886plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCIEAGO:0005923bicellular tight junction
BPIEAGO:0007162negative regulation of cell adhesion
BPTASGO:0030198extracellular matrix organization
BPTASGO:0050900leukocyte migration
BPNASGO:0098609cell-cell adhesion

Gene expression in normal tissue: JAM2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in JAM2


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-216083Integrin cell surface interactions
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
pidamb2_neutrophils_pathwayamb2 Integrin signaling
pidintegrin1_pathwayBeta1 integrin cell surface interactions
pidintegrin_a4b1_pathwayAlpha4 beta1 integrin signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JAM2

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