JRK
Summary: This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Jrk helix-turn-helix protein | MIM:603210 | Ensembl:ENSG00000234616 | HGNC:HGNC:6199 | PA30001 | 8q24.3 |
GO terms in JRK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| CC | ND | GO:0005575 | cellular_component |
| CC | IEA | GO:0005634 | nucleus |
| BP | IMP | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
Gene expression in normal tissue: JRK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in JRK
| Database | Pathway ID | Pathway Des. |
|---|
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in JRK
CLASSFICATION
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